{"id":"W4392022791","doi":"10.1021/jacs.3c07023","title":"Exceptional Nuclease Resistance of DNA and RNA with the Addition of Small-Molecule Nucleobase Mimics","year":2024,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canada Council for the Arts; Research Corporation for Science Advancement","keywords":"Nucleic acid; Nuclease; Chemistry; Nucleobase; DNA; RNA; Cyanuric acid; Supramolecular chemistry; Nucleic acid structure; Stereochemistry; Steric effects; Biochemistry; Combinatorial chemistry; Molecule; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268046,0.0002761297,0.0002149244,0.0001324503,0.0001410908,0.000347696,0.0002470552,0.0003555503,0.0003486254],"category_scores_gemma":[0.0006140094,0.0001530335,0.0001768355,0.00008847663,0.0002799712,0.0002979795,0.0003037355,0.0004559941,0.0001846255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001733573,"about_ca_system_score_gemma":0.0001624484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001726496,"about_ca_topic_score_gemma":0.0003630909,"domain_scores_codex":[0.999696,0.00005118808,0.00002537825,0.00008808228,0.0001050971,0.00003420577],"domain_scores_gemma":[0.9996247,0.00009525675,0.0001445137,0.00005847665,0.00003849073,0.00003853576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001341729,0.000004363294,0.00007238935,0.00001740743,0.000002931861,0.00002104761,0.00001270968,0.00006568817,0.9985447,0.0000917576,0.000007581663,0.001145859],"study_design_scores_gemma":[0.00000139161,0.00007134175,0.000251583,0.000001005472,0.000002660636,0.0001079674,0.000003527544,0.0003612781,0.9987127,0.00002450811,0.0004597075,0.000002400864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673175,0.001914519,0.02837862,0.0001301467,0.00003225693,0.00004506498,0.0000717879,0.0002791907,0.001830977],"genre_scores_gemma":[0.9881425,0.0003780384,0.01051694,0.00004110353,0.00001005727,0.00003202609,0.00005861287,0.00002251991,0.0007981273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003555503,"threshold_uncertainty_score":0.001417577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005371146387109488,"score_gpt":0.2351386492868199,"score_spread":0.2297675028997104,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}