{"id":"W4392040529","doi":"10.1111/dmcn.15885","title":"State‐of‐the‐art therapies for fragile X syndrome","year":2024,"lang":"en","type":"review","venue":"Developmental Medicine & Child Neurology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Child Health and Human Development; Science Fund of the Republic of Serbia; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Azrieli Foundation","keywords":"Fragile X syndrome; Autism spectrum disorder; Anxiety; Intellectual disability; Medicine; Autism; FMR1; Psychiatry; Sertraline; Psychological intervention; Pharmacotherapy; Fragile x; Genetics; Antidepressant; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001708877,0.0005940467,0.001076474,0.0001723251,0.000124928,0.000009818398,0.0006695554,0.0002937974,0.00004819462],"category_scores_gemma":[0.00008674469,0.0003850113,0.0003901696,0.0002805988,0.0003806451,0.000001980933,0.0004729903,0.000385779,0.00004559294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001669658,"about_ca_system_score_gemma":0.0002958543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002532751,"about_ca_topic_score_gemma":0.00002161187,"domain_scores_codex":[0.9976135,0.0001178966,0.0007971115,0.0008185021,0.0002282285,0.0004247099],"domain_scores_gemma":[0.9991688,0.00004134973,0.0002723728,0.0003855377,0.00004231785,0.00008965324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000951529,0.0001646519,0.0000645273,0.01071219,0.001211926,0.00005151459,0.0002746328,0.000003860791,0.0008658076,0.00006653857,0.08186231,0.9046269],"study_design_scores_gemma":[0.0003743932,0.000656078,0.0004033303,0.001273795,0.000283239,0.0007385662,0.000006275602,6.229822e-7,0.000137618,0.0001048132,0.9956732,0.0003481178],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002874533,0.9914516,0.00001798269,0.001294299,0.001882036,0.001451128,0.0001432966,0.00002133361,0.0008637812],"genre_scores_gemma":[0.002463256,0.9922772,0.0001384723,0.002319886,0.0000797855,0.0002955543,0.000520878,0.0001443911,0.001760589],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9138108,"threshold_uncertainty_score":0.9998602,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01645748591190057,"score_gpt":0.2737163969403177,"score_spread":0.2572589110284172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}