{"id":"W4392051559","doi":"10.7759/cureus.54668","title":"Enhancing Antimicrobial Efficacy and Synergistic Effects of Nano-Silica-Based Combinations With Doxycycline, Metronidazole, and Ciprofloxacin Against Enterococcus faecalis Biofilms","year":2024,"lang":"en","type":"article","venue":"Cureus","topic":"Endodontics and Root Canal Treatments","field":"Dentistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Global Health Research","funders":"","keywords":"Enterococcus faecalis; Biofilm; Antimicrobial; Ciprofloxacin; Metronidazole; Endodontics; Antibiotics; Microbiology; Silver nanoparticle; Chemistry; Doxycycline; Nanotechnology; Materials science; Nanoparticle; Medicine; Biology; Dentistry; Bacteria; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002007305,0.00028579,0.0003276868,0.0003225924,0.0001027969,0.0002074653,0.0001707102,0.0002364282,0.0006328401],"category_scores_gemma":[0.0002284624,0.0001712394,0.0003477271,0.000105755,0.0001880635,0.0002211423,0.000208266,0.0002161091,0.0001223012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000204306,"about_ca_system_score_gemma":0.0001693143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003689871,"about_ca_topic_score_gemma":0.001271862,"domain_scores_codex":[0.9998124,0.00003303536,0.00001942784,0.00003949568,0.00006524916,0.00003044278],"domain_scores_gemma":[0.9998813,0.00003702105,0.00002945016,0.000008104465,0.00002241638,0.00002175339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001955311,0.00008224496,0.000230738,0.0001004352,0.00001614634,0.00002394433,0.0000114639,0.0002628347,0.9943749,0.00002216309,0.00004752457,0.004632093],"study_design_scores_gemma":[0.00002614954,0.001677359,0.002804145,0.00001498146,0.0000519936,0.00009559366,0.0000170384,0.001548917,0.992493,0.00001147259,0.001249216,0.00001029567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947577,0.002738248,0.001105656,0.00005159277,0.00003471334,0.00003633409,0.00004799408,0.00002378523,0.001204042],"genre_scores_gemma":[0.9952418,0.0009328023,0.003274616,0.00003109166,0.00001234587,0.00002766808,0.00003958193,0.000005830056,0.0004343241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006328401,"threshold_uncertainty_score":0.002117097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006532223586731772,"score_gpt":0.2509835099785481,"score_spread":0.2444512863918163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}