{"id":"W4392058118","doi":"10.1038/s41594-024-01233-6","title":"The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction","year":2024,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Sinai Health System; Institute for Research in Immunology and Cancer; Université de Montréal; Lunenfeld-Tanenbaum Research Institute","funders":"Argonne National Laboratory; National Institute of General Medical Sciences; Office of Research Infrastructure Programs, National Institutes of Health; Canadian Institutes of Health Research; Canada Research Chairs; Office of Science; National Institutes of Health; Fondation pour la Recherche Médicale; U.S. Department of Energy","keywords":"MAPK/ERK pathway; Scaffold protein; Cell biology; Allosteric regulation; Kinase; MEK inhibitor; Small GTPase; Chemistry; Phosphorylation; Biology; Signal transduction; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001843332,0.0002760261,0.0001757028,0.00006172289,0.0002746828,0.0001217617,0.0002853878,0.0005631468,0.00002869584],"category_scores_gemma":[0.0001889656,0.0001904333,0.0001516026,0.0001564107,0.0001160421,0.00001286983,0.000139158,0.0005001698,0.000009487519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004432785,"about_ca_system_score_gemma":0.0000633512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002017629,"about_ca_topic_score_gemma":0.00002283694,"domain_scores_codex":[0.998464,0.000167206,0.0002658441,0.0005794397,0.000124529,0.0003989484],"domain_scores_gemma":[0.9993644,0.00005043518,0.00009566398,0.0003210683,0.00009702066,0.0000713484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005687649,0.000003817654,0.00003429268,0.00002373752,0.0001050869,0.000005773473,0.00003332594,0.000005246229,0.97679,0.004205494,0.00238059,0.01635582],"study_design_scores_gemma":[0.0001719124,0.0002074784,0.00016757,0.00002753455,0.00002042235,0.00007617915,0.00005205227,0.0003479115,0.871233,0.001516959,0.1259561,0.0002228484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9823347,0.006500295,0.007366124,0.001106531,0.001482996,0.0003520575,0.00004443532,0.00007537133,0.0007375437],"genre_scores_gemma":[0.9969769,0.00008437972,0.0005214207,0.0005539849,0.0004606533,0.00002791041,0.001072273,0.00003651952,0.0002660253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1235755,"threshold_uncertainty_score":0.7765644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005813699272387353,"score_gpt":0.3001666915955278,"score_spread":0.2943529923231405,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}