{"id":"W4392058223","doi":"10.1177/01926233241229808","title":"Adeno-Associated Virus-Mediated Dorsal Root Ganglion Toxicity in the New Zealand White Rabbit","year":2024,"lang":"en","type":"article","venue":"Toxicologic Pathology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Dorsal root ganglion; Adeno-associated virus; Cisterna magna; Spinal cord; Transgene; Sensory neuron; Biology; Histopathology; Neurotoxicity; Pathology; Mononuclear cell infiltration; Toxicity; Sensory system; Medicine; Recombinant DNA; Neuroscience; Internal medicine; Vector (molecular biology); Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001485998,0.0002783929,0.0002921439,0.0001816639,0.00009318642,0.00006630323,0.0006036418,0.0006110073,0.0003440519],"category_scores_gemma":[0.0004457097,0.0002013246,0.0001327468,0.0005093475,0.0001943714,0.000007824582,0.0001740558,0.0005609078,0.0002144416],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008131655,"about_ca_system_score_gemma":0.0002852959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002944273,"about_ca_topic_score_gemma":0.003354742,"domain_scores_codex":[0.9970149,0.0009999014,0.0003458678,0.00066613,0.000258359,0.0007148236],"domain_scores_gemma":[0.9991463,0.0001474183,0.00006962499,0.0004913848,0.00004356642,0.0001017098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007838865,0.000263429,0.003201297,0.000008584005,0.00005477248,0.0007648939,0.000499505,0.00009364755,0.9655998,0.00002773268,0.0263361,0.002366325],"study_design_scores_gemma":[0.006326299,0.03022574,0.1151938,0.00008672324,0.0001259994,0.0008716272,0.0004544329,0.0008092984,0.7419838,0.004016093,0.09820366,0.001702512],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913251,0.003147173,0.00007878678,0.003610975,0.0003039097,0.0004665513,0.0000702641,0.00008624707,0.00091101],"genre_scores_gemma":[0.9947171,0.0003010635,0.00002888352,0.001756125,0.0002755575,0.00008157309,0.0003127252,0.00003596231,0.002490991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.223616,"threshold_uncertainty_score":0.820978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01835174970843826,"score_gpt":0.2947912072017405,"score_spread":0.2764394574933022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}