{"id":"W4392058223","doi":"10.1177/01926233241229808","title":"Adeno-Associated Virus-Mediated Dorsal Root Ganglion Toxicity in the New Zealand White Rabbit","year":2024,"lang":"en","type":"article","venue":"Toxicologic Pathology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Dorsal root ganglion; Adeno-associated virus; Cisterna magna; Spinal cord; Transgene; Sensory neuron; Biology; Histopathology; Neurotoxicity; Pathology; Mononuclear cell infiltration; Toxicity; Sensory system; Medicine; Recombinant DNA; Neuroscience; Internal medicine; Vector (molecular biology); Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007300391,0.0005176002,0.0004261248,0.0006031216,0.0003012478,0.0004796103,0.0003435366,0.0004864861,0.0009616118],"category_scores_gemma":[0.0005104793,0.0002953269,0.0004853364,0.0002210555,0.0006108782,0.0004847412,0.0002952804,0.0006606851,0.0005018323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004720289,"about_ca_system_score_gemma":0.0003840661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002503599,"about_ca_topic_score_gemma":0.002726823,"domain_scores_codex":[0.9994135,0.000113628,0.0000694176,0.0001759091,0.0001573036,0.00007029283],"domain_scores_gemma":[0.9996226,0.00005884682,0.0001459565,0.00008193409,0.0000495084,0.00004121406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002663133,0.0001095993,0.0003459878,0.00006098643,0.00001576505,0.0001875135,0.00009653344,0.00007956717,0.9963414,0.0002842386,0.00004541502,0.002166655],"study_design_scores_gemma":[0.00009579575,0.006685472,0.004794961,0.00004220542,0.00008814074,0.001999782,0.0001364358,0.001158268,0.9803187,0.0001907127,0.004473453,0.00001600465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986245,0.001790993,0.007483428,0.0001575337,0.00007027976,0.0002722811,0.0002369751,0.0001348892,0.003608607],"genre_scores_gemma":[0.9799587,0.002985562,0.007912625,0.00009943336,0.00001717539,0.0002775067,0.0003818288,0.00004911279,0.008318065],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002503599,"threshold_uncertainty_score":0.004978001,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01835174970843826,"score_gpt":0.2947912072017405,"score_spread":0.2764394574933022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}