{"id":"W4392058892","doi":"10.12688/gatesopenres.15323.1","title":"Taking stock: Is gene drive research delivering on its principles?","year":2024,"lang":"en","type":"preprint","venue":"Gates Open Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; McMaster University","funders":"McMaster University; World Health Organization; Bill and Melinda Gates Foundation","keywords":"Accountability; Transparency (behavior); Gene drive; Political science; Engineering ethics; Public relations; Biotechnology; Engineering; Gene; Biology; Law; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","open_science","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.004510673,0.000408404,0.0003824056,0.0005356321,0.0004268828,0.001013639,0.00269329,0.0006479089,0.0003068761],"category_scores_gemma":[0.0006878955,0.0004068621,0.0001751919,0.0004749412,0.0001811662,0.000004805556,0.02206866,0.003182103,0.0005883809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021279,"about_ca_system_score_gemma":0.0007132131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006139183,"about_ca_topic_score_gemma":0.0001442854,"domain_scores_codex":[0.9947235,0.0004366245,0.0004327897,0.001784178,0.001305391,0.001317493],"domain_scores_gemma":[0.9968954,0.0001362591,0.00007270146,0.001620342,0.0009691496,0.000306182],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003928888,0.0002051292,0.0004460303,0.00147221,0.0006326441,0.0002679135,0.00129063,0.01584374,0.9368336,0.001464154,0.0227605,0.01839062],"study_design_scores_gemma":[0.0003601405,0.0005244526,0.001143134,0.000960533,0.00001824809,0.00001677489,0.0002172062,0.006006305,0.9242806,0.0009080798,0.06495982,0.0006047548],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9392437,0.01054861,0.0002109077,0.001233202,0.0005984124,0.003056165,0.0002211066,0.00004715065,0.04484069],"genre_scores_gemma":[0.9810815,0.002567825,0.001190379,0.0000694909,0.0009398644,0.0007344196,0.0002482108,0.0001674266,0.01300083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04219932,"threshold_uncertainty_score":0.9998384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2693152094924604,"score_gpt":0.520938433301307,"score_spread":0.2516232238088466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}