{"id":"W4392058892","doi":"10.12688/gatesopenres.15323.1","title":"Taking stock: Is gene drive research delivering on its principles?","year":2024,"lang":"en","type":"preprint","venue":"Gates Open Research","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; McMaster University","funders":"McMaster University; World Health Organization; Bill and Melinda Gates Foundation","keywords":"Accountability; Transparency (behavior); Gene drive; Political science; Engineering ethics; Public relations; Biotechnology; Engineering; Gene; Biology; Law; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.03318843,0.0006888358,0.001063373,0.001439071,0.006496608,0.02240346,0.002212597,0.00939685,0.01084001],"category_scores_gemma":[0.07714158,0.000438594,0.0007750841,0.002323125,0.02626635,0.01746023,0.006685022,0.01268962,0.005042327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007461124,"about_ca_system_score_gemma":0.01824248,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004626698,"about_ca_topic_score_gemma":0.003871974,"domain_scores_codex":[0.9610057,0.01351163,0.001735644,0.003938424,0.01683133,0.002977408],"domain_scores_gemma":[0.9353707,0.03849732,0.004513307,0.008365535,0.008990535,0.004262626],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00007387364,0.00004775676,0.001858581,0.0004375418,0.00003081192,0.0003904343,0.005649733,0.000306271,0.00177993,0.7841388,0.1020421,0.1032441],"study_design_scores_gemma":[0.00001303155,0.00009798457,0.001237844,0.0005964158,0.00002991939,0.0003706896,0.005165162,0.0003749486,0.002773988,0.2334025,0.755856,0.00008140841],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.01316424,0.01353544,0.0376259,0.7909567,0.01135283,0.0001562546,0.0002782888,0.0005548692,0.1323754],"genre_scores_gemma":[0.4455098,0.03304583,0.04933334,0.3342525,0.005759658,0.0005615161,0.0006940947,0.001612632,0.1292307],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.9668116,"threshold_uncertainty_score":0.1755193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2693152094924604,"score_gpt":0.520938433301307,"score_spread":0.2516232238088466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}