{"id":"W4392059660","doi":"10.1016/s2468-1253(24)00034-7","title":"A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial","year":2024,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Medical Research Council; Cambridge University Hospitals; King's College London; National Institute for Health and Care Research; Queen Elizabeth Hospital Birmingham Charity; Crohn's and Colitis UK; University of Cambridge; University Hospitals Bristol NHS Foundation Trust; NIHR Cambridge Biomedical Research Centre; Francis Crick Institute; Wellcome Trust","keywords":"Medicine; Crohn's disease; Open label; Randomized controlled trial; Biomarker; Disease; Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003225176,0.0006039733,0.00146865,0.0001176789,0.0002112484,0.0001702532,0.0007572838,0.0002714235,0.00005228657],"category_scores_gemma":[0.0001239357,0.0004126438,0.0003039822,0.0001129595,0.0005051115,0.00003499198,0.0001837238,0.0001875397,0.000008380062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008071843,"about_ca_system_score_gemma":0.0007137677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005529244,"about_ca_topic_score_gemma":0.001550789,"domain_scores_codex":[0.9960615,0.0008771382,0.0009820276,0.0009441354,0.0002019307,0.0009332559],"domain_scores_gemma":[0.9977828,0.0004021822,0.0003939169,0.0008523802,0.0003073548,0.0002613163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9369574,0.002044551,0.05337821,0.0001174063,0.00218729,0.0001980854,0.0001429073,0.00004437602,0.001646064,0.0001189347,0.001992447,0.001172353],"study_design_scores_gemma":[0.9526581,0.008056368,0.02353745,0.00004198798,0.001167128,0.000003842362,0.000187991,0.01274204,0.0001689374,0.00002305224,0.001103627,0.000309459],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9844341,0.0003172239,0.002330403,0.0002493575,0.001525667,0.01036234,0.0006398145,0.0000600134,0.00008111614],"genre_scores_gemma":[0.992591,0.00004893766,0.0003783898,0.0002838305,0.0002867226,0.004873124,0.001375888,0.00006575283,0.00009637353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02984077,"threshold_uncertainty_score":0.9998325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03499606865928696,"score_gpt":0.3159158013540203,"score_spread":0.2809197326947334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}