{"id":"W4392059660","doi":"10.1016/s2468-1253(24)00034-7","title":"A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial","year":2024,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":281,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Medical Research Council; Cambridge University Hospitals; King's College London; National Institute for Health and Care Research; Queen Elizabeth Hospital Birmingham Charity; Crohn's and Colitis UK; University of Cambridge; University Hospitals Bristol NHS Foundation Trust; NIHR Cambridge Biomedical Research Centre; Francis Crick Institute; Wellcome Trust","keywords":"Medicine; Crohn's disease; Open label; Randomized controlled trial; Biomarker; Disease; Internal medicine; Oncology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0040305,0.002629909,0.004988682,0.0005536724,0.0005379171,0.001747575,0.001224656,0.002992456,0.005584674],"category_scores_gemma":[0.004811698,0.0008948731,0.003498179,0.0005966378,0.001525065,0.002061884,0.0009584964,0.002759553,0.0009263195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001079319,"about_ca_system_score_gemma":0.00142089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008310973,"about_ca_topic_score_gemma":0.001225338,"domain_scores_codex":[0.9974793,0.001429847,0.0001982665,0.0004717438,0.0001595591,0.0002613152],"domain_scores_gemma":[0.9968762,0.000971503,0.000934796,0.0002968709,0.0002209088,0.0006997413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9932404,0.002051092,0.0003094694,0.0003079217,0.0006106924,0.00001055488,0.00002350179,0.00009608717,0.000433929,0.00003564806,0.00009475114,0.002785952],"study_design_scores_gemma":[0.9503365,0.04758123,0.0009494006,0.00003019582,0.0005208779,0.00001054791,0.00001226631,0.0002121457,0.00009605313,0.0001087155,0.0001306077,0.00001147658],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828532,0.004109364,0.0009683889,0.000638004,0.0009195331,0.008412242,0.0008496213,0.00008858631,0.001161018],"genre_scores_gemma":[0.979582,0.001663406,0.003297132,0.001123339,0.0008627742,0.01132615,0.0007558008,0.00001958153,0.001369857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005584674,"threshold_uncertainty_score":0.02131557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03499606865928696,"score_gpt":0.3159158013540203,"score_spread":0.2809197326947334,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}