{"id":"W4392088576","doi":"10.1093/eurjpc/zwae075","title":"Interaction between type 2 diabetes polygenic risk and physical activity on cardiovascular outcomes","year":2024,"lang":"en","type":"article","venue":"European Journal of Preventive Cardiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Japan Health Foundation; Mishima Kaiun Memorial Foundation; Taichung Veterans General Hospital; SENSHIN Medical Research Foundation; Danone Institute of Japan Foundation; Health Research Foundation; Senri Life Science Foundation; Japan Foundation for Applied Enzymology; Takeda Science Foundation","keywords":"Medicine; Type 2 diabetes; Physical activity; Diabetes mellitus; Polygenic risk score; Internal medicine; Physical therapy; Endocrinology; Genetics; Gene; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001369943,0.0001377016,0.0004450021,0.00007675164,0.0000521724,0.00001530993,0.0001079783,0.00005638797,0.00000277352],"category_scores_gemma":[0.0005050583,0.000106467,0.000517868,0.00006049811,0.00007490828,0.000006638373,0.00008872732,0.0002888791,0.00002015812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001948704,"about_ca_system_score_gemma":0.00002912888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001412726,"about_ca_topic_score_gemma":2.181301e-7,"domain_scores_codex":[0.9973241,0.001983574,0.0002007808,0.0002371479,0.00008377619,0.0001706412],"domain_scores_gemma":[0.9993415,0.0001643018,0.0001531851,0.0001816686,0.00009438933,0.00006494037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001282129,0.0000707946,0.5913233,0.00003696222,0.01170788,0.0001002214,0.0002193028,0.001698353,0.02673387,0.00003265272,0.004491061,0.3634574],"study_design_scores_gemma":[0.0003082196,0.001134637,0.9662943,0.00002553769,0.0004780623,0.0000383088,0.00004270898,0.00003534869,0.001223102,0.0001270238,0.03015928,0.0001334282],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915203,0.003142445,0.003779939,0.000105562,0.0006427928,0.00006399269,0.00001960449,0.000006225077,0.0007191565],"genre_scores_gemma":[0.9976727,0.0008881869,0.0001289866,0.00002914437,0.001133914,0.000001021563,0.000009607053,0.00002157937,0.0001148929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3749711,"threshold_uncertainty_score":0.4341599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648076451053715,"score_gpt":0.2810402606953521,"score_spread":0.2645594961848149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}