{"id":"W4392088576","doi":"10.1093/eurjpc/zwae075","title":"Interaction between type 2 diabetes polygenic risk and physical activity on cardiovascular outcomes","year":2024,"lang":"en","type":"article","venue":"European Journal of Preventive Cardiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Japan Health Foundation; Mishima Kaiun Memorial Foundation; Taichung Veterans General Hospital; SENSHIN Medical Research Foundation; Danone Institute of Japan Foundation; Health Research Foundation; Senri Life Science Foundation; Japan Foundation for Applied Enzymology; Takeda Science Foundation","keywords":"Medicine; Type 2 diabetes; Physical activity; Diabetes mellitus; Polygenic risk score; Internal medicine; Physical therapy; Endocrinology; Genetics; Gene; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001997544,0.0005562243,0.0006427688,0.0005749182,0.0003588934,0.0007361788,0.0003677832,0.0005881517,0.002003612],"category_scores_gemma":[0.003801217,0.0003075765,0.001630407,0.0008748877,0.0003436569,0.000250255,0.000740295,0.0008711278,0.0001453252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002569942,"about_ca_system_score_gemma":0.0004314131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01009598,"about_ca_topic_score_gemma":0.009762325,"domain_scores_codex":[0.996887,0.001819176,0.0001582017,0.0005567136,0.0002788712,0.0002999559],"domain_scores_gemma":[0.9956462,0.002126946,0.0009587351,0.0007063248,0.0001915017,0.0003702966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000930894,0.0000673922,0.9929576,0.00002145124,0.001349721,0.0001156566,0.00003742391,0.0003252905,0.001091027,0.00006199858,0.00008589479,0.002955606],"study_design_scores_gemma":[0.00001094489,0.0001168472,0.9987202,0.000004210265,0.0002781828,0.00006940174,0.00001080343,0.0005803864,0.00007568052,0.0000671673,0.00006241598,0.000003835607],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967439,0.0007418651,0.001073539,0.0001405948,0.0000152537,0.0000123297,0.0006986397,0.00002184725,0.0005520265],"genre_scores_gemma":[0.998892,0.0001182079,0.0004235049,0.00003631961,0.00001114484,0.00001226487,0.000317281,0.000004618846,0.0001846616],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01009598,"threshold_uncertainty_score":0.02007443,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01648076451053715,"score_gpt":0.2810402606953521,"score_spread":0.2645594961848149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}