{"id":"W4392091868","doi":"10.1093/neuonc/noae011","title":"Cancer stem cell hypothesis 2.0 in glioblastoma: Where are we now and where are we going?","year":2024,"lang":"en","type":"review","venue":"Neuro-Oncology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Case Comprehensive Cancer Center, Case Western Reserve University","keywords":"Cancer stem cell; Biology; Phenotype; Stem cell; Tumor initiation; Glioblastoma; Cancer; Computational biology; Neuroscience; Population; Cancer research; Carcinogenesis; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002530417,0.000916025,0.00422422,0.0006045419,0.0000683291,0.00005662781,0.0002968486,0.0009697615,0.0004101405],"category_scores_gemma":[0.00001999869,0.0007223913,0.0006456914,0.0008138063,0.0001981461,0.0000634445,0.0003033381,0.001814313,0.0003340114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001154092,"about_ca_system_score_gemma":0.001530878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009274726,"about_ca_topic_score_gemma":0.01494281,"domain_scores_codex":[0.996017,0.0004460694,0.001035111,0.001377461,0.0003580919,0.0007663047],"domain_scores_gemma":[0.9975101,0.0005356591,0.0007762291,0.0006880824,0.00009072122,0.0003991719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001129541,0.0001771696,0.00009229147,0.08563822,0.0001759855,0.003295092,0.0001577535,9.401692e-7,0.00009555844,0.00000294702,0.1475239,0.7627273],"study_design_scores_gemma":[0.001181116,0.0006824996,0.000004838221,0.03261988,0.003986001,0.0006803341,0.0003043109,0.000004993419,0.00006582385,0.000009532325,0.9599629,0.0004977693],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001449418,0.9837089,0.000001119601,0.01048499,0.001911161,0.00153313,0.0003264112,0.0001149377,0.001774472],"genre_scores_gemma":[0.000054637,0.9920313,0.00006668944,0.0006195205,0.001029834,0.0005523777,0.000004757982,0.0002634534,0.0053774],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.812439,"threshold_uncertainty_score":0.9995227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05658437933905237,"score_gpt":0.336925615272217,"score_spread":0.2803412359331646,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}