{"id":"W4392094083","doi":"10.1126/sciadv.adk9004","title":"An orally active entry inhibitor of influenza A viruses protects mice and synergizes with oseltamivir and baloxavir marboxil","year":2024,"lang":"en","type":"article","venue":"Science Advances","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Neuraminidase inhibitor; Oseltamivir; Pharmacology; Hemagglutinin (influenza); Drug; Bioavailability; Medicine; Influenza A virus; In vivo; Antiviral drug; Virology; Virus; Immunology; Biology; Internal medicine; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174574,0.0006667681,0.0005474988,0.0003787879,0.0001081182,0.0002018925,0.0003127494,0.0002924725,0.001230302],"category_scores_gemma":[0.00007860532,0.0001558269,0.0003426848,0.0001192735,0.0002126265,0.0002457178,0.0001585913,0.0007527518,0.0003890134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001017594,"about_ca_system_score_gemma":0.0002191464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002420352,"about_ca_topic_score_gemma":0.0004453676,"domain_scores_codex":[0.9998832,0.00002906977,0.000008216921,0.00001551174,0.00002314942,0.00004088278],"domain_scores_gemma":[0.9999183,0.000009267716,0.00002019935,0.000007342036,0.000005363537,0.00003958392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002859065,0.0009819831,0.000281218,0.0001136117,0.00002970541,0.00006658994,0.00001728659,0.0002115465,0.9833149,0.0001322892,0.0001796023,0.01181223],"study_design_scores_gemma":[0.0006539409,0.01684346,0.005525802,0.00001966876,0.00007954908,0.0003881306,0.0000260266,0.001776842,0.9707357,0.00007954385,0.003859635,0.00001174973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912261,0.003495318,0.001857209,0.0001695999,0.00008818752,0.00008359625,0.0003031257,0.0001829354,0.002593976],"genre_scores_gemma":[0.9924778,0.0019103,0.001651141,0.00005861144,0.00004081153,0.0000596399,0.0005781981,0.00001951671,0.003203847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001230302,"threshold_uncertainty_score":0.00411576,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03001180781573558,"score_gpt":0.3773844787591316,"score_spread":0.347372670943396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}