{"id":"W4392095749","doi":"10.26508/lsa.202302348","title":"Galectin-8 modulates human osteoclast activity partly through isoform-specific interactions","year":2024,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Faculté de médecine et des sciences de la santé, Université de Sherbrooke; Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec; Université de Sherbrooke","keywords":"Gene isoform; Osteoclast; Alternative splicing; Cell biology; Galectin; Bone resorption; HEK 293 cells; Chemistry; Biology; Receptor; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003083739,0.0002159647,0.000234791,0.00009575797,0.0008879156,0.0001562947,0.0005294245,0.000124095,0.001087259],"category_scores_gemma":[0.00005773413,0.0001837165,0.0001051106,0.0009293939,0.00125461,0.0008233516,0.0001386122,0.0005364669,0.001459905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001339989,"about_ca_system_score_gemma":0.0002476169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001177894,"about_ca_topic_score_gemma":0.0001504289,"domain_scores_codex":[0.9981341,0.0000670512,0.0002419147,0.0007907479,0.00007657552,0.0006896564],"domain_scores_gemma":[0.9992627,0.0001027207,0.00007863873,0.0004134157,0.00009128539,0.00005127756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000277289,0.00006223942,0.0008245161,0.00001665294,0.00003880867,0.000004784701,0.0005785452,0.00002805367,0.9740988,0.00538935,0.01146726,0.007463261],"study_design_scores_gemma":[0.0003154987,0.0002819498,0.01113384,0.0001175818,0.00001755344,0.0001100073,0.000408984,0.00009545013,0.4357576,0.001470871,0.549889,0.000401603],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740372,0.005716886,0.0008177751,0.001425148,0.005254821,0.0002138493,0.00002390103,0.0002810688,0.01222934],"genre_scores_gemma":[0.9917758,0.0003401884,0.0001106415,0.0002972297,0.0002115075,0.00005053734,0.00001059974,0.00001605967,0.00718744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5384218,"threshold_uncertainty_score":0.9998259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03935363383300616,"score_gpt":0.3211396931905976,"score_spread":0.2817860593575914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}