{"id":"W4392096926","doi":"10.1038/s41398-024-02811-4","title":"Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study","year":2024,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; University of Toronto; Montreal Neurological Institute and Hospital; Dalhousie University","funders":"National Cancer Institute; National Institute of Mental Health; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Ministry of Education, India; Virginia Commonwealth University; Vetenskapsrådet; Centro de Investigación Biomédica en Red de Salud Mental; National Alliance for Research on Schizophrenia and Depression; Karolinska Institutet; Ministerstvo Zdravotnictví Ceské Republiky; Bundesministerium für Bildung und Forschung; University of California, San Diego; U.S. Department of Veterans Affairs; University of New South Wales; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Oxford; Broad Institute; Genome Canada; Alfried Krupp von Bohlen und Halbach-Stiftung; National Institute on Drug Abuse; Stanley Center for Psychiatric Research, Broad Institute; University of Pennsylvania; Universidad de Antioquia; Deutsche Forschungsgemeinschaft; University of Louisville; Johns Hopkins University; Brain and Behavior Research Foundation; Rush University; Wayne State University; National Science Foundation","keywords":"PI3K/AKT/mTOR pathway; Focal adhesion; Protein kinase B; Bipolar disorder; Lithium (medication); Genome-wide association study; Pharmacogenomics; Signal transduction; Bioinformatics; Neuroscience; Biology; Medicine; Computational biology; Genetics; Single-nucleotide polymorphism; Psychiatry; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004398633,0.0001852563,0.0002108357,0.0001778053,0.00008164562,0.00003244481,0.00004132325,0.0001290458,0.00002804191],"category_scores_gemma":[0.00001849892,0.0001477733,0.00006074623,0.0004505323,0.00004454682,0.0001041158,0.000007324591,0.0002793018,0.000009100234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000451894,"about_ca_system_score_gemma":0.0001949491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006734217,"about_ca_topic_score_gemma":0.001244234,"domain_scores_codex":[0.9986556,0.0001243052,0.0002884465,0.0004992035,0.0002511343,0.000181366],"domain_scores_gemma":[0.9994422,0.0001336565,0.00003572973,0.0002652976,0.00004185398,0.00008124312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002618963,0.001910647,0.9870664,0.00004313798,0.0002474218,0.000007491088,0.001683351,0.0001245526,0.00004078917,0.0001561077,0.0000834493,0.006017664],"study_design_scores_gemma":[0.004727503,0.001083823,0.9696824,0.0001987449,0.000241875,0.00002194133,0.0002242153,0.02217116,0.000003989647,0.0002556386,0.001233447,0.0001552805],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9470922,0.04045846,0.00343373,0.007615973,0.0001442324,0.001047085,0.0000495985,0.0001137473,0.00004492557],"genre_scores_gemma":[0.9978403,0.000135871,0.001309459,0.0001854108,0.00005626783,0.00006598591,0.0001545479,0.00003907069,0.0002130169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05074813,"threshold_uncertainty_score":0.6026019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181347201021747,"score_gpt":0.2981039581591953,"score_spread":0.2799692380570206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}