{"id":"W4392096926","doi":"10.1038/s41398-024-02811-4","title":"Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study","year":2024,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University; Douglas Mental Health University Institute; McGill University Health Centre; University of Toronto; Montreal Neurological Institute and Hospital; Dalhousie University","funders":"National Cancer Institute; National Institute of Mental Health; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Rheinische Friedrich-Wilhelms-Universität Bonn; Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Ministry of Education, India; Virginia Commonwealth University; Vetenskapsrådet; Centro de Investigación Biomédica en Red de Salud Mental; National Alliance for Research on Schizophrenia and Depression; Karolinska Institutet; Ministerstvo Zdravotnictví Ceské Republiky; Bundesministerium für Bildung und Forschung; University of California, San Diego; U.S. Department of Veterans Affairs; University of New South Wales; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; University of Oxford; Broad Institute; Genome Canada; Alfried Krupp von Bohlen und Halbach-Stiftung; National Institute on Drug Abuse; Stanley Center for Psychiatric Research, Broad Institute; University of Pennsylvania; Universidad de Antioquia; Deutsche Forschungsgemeinschaft; University of Louisville; Johns Hopkins University; Brain and Behavior Research Foundation; Rush University; Wayne State University; National Science Foundation","keywords":"PI3K/AKT/mTOR pathway; Focal adhesion; Protein kinase B; Bipolar disorder; Lithium (medication); Genome-wide association study; Pharmacogenomics; Signal transduction; Bioinformatics; Neuroscience; Biology; Medicine; Computational biology; Genetics; Single-nucleotide polymorphism; Psychiatry; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001636924,0.0006543333,0.0008678466,0.0006018523,0.001042723,0.00113017,0.0005231096,0.0007217124,0.00217245],"category_scores_gemma":[0.003734836,0.0003835637,0.001359597,0.001191343,0.0003101944,0.0003760924,0.0007397665,0.0007792228,0.0004302764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007214125,"about_ca_system_score_gemma":0.0006724416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01076585,"about_ca_topic_score_gemma":0.01361167,"domain_scores_codex":[0.998997,0.0003017402,0.0001038731,0.0003514116,0.0001318167,0.0001140915],"domain_scores_gemma":[0.9986905,0.0001841429,0.0003993426,0.0003274392,0.0002996976,0.00009892359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005172394,0.0002263367,0.9371112,0.0005032407,0.005360555,0.0008557478,0.0007202141,0.0006961992,0.02198068,0.0003871521,0.004454626,0.02253167],"study_design_scores_gemma":[0.0004120815,0.0002915226,0.990508,0.0000607512,0.002291656,0.0008062372,0.0002505885,0.001062765,0.001242311,0.0005907312,0.002448249,0.00003517727],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987041,0.00193445,0.002096429,0.0003932797,0.00005826618,0.0001346965,0.00722899,0.00005612127,0.001056894],"genre_scores_gemma":[0.9910477,0.0003936241,0.001529631,0.0002395031,0.00003668551,0.0002505977,0.005927518,0.00003971676,0.000535122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01076585,"threshold_uncertainty_score":0.02140635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0181347201021747,"score_gpt":0.2981039581591953,"score_spread":0.2799692380570206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}