{"id":"W4392108261","doi":"10.3389/fphar.2024.1368620","title":"Intravenous Reelin rescues despair-like behavior, Reelin cells in the dentate sub-granular zone, and spleen atrophy in the cyclic corticosterone model of recurring depressive episodes","year":2024,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Reelin; Dentate gyrus; Behavioural despair test; Chronic stress; Atrophy; White pulp; Hippocampus; Medicine; Hippocampal formation; Internal medicine; Spleen; Endocrinology; Psychology; Antidepressant; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001381197,0.0006975663,0.0007527303,0.0004841095,0.0001613831,0.0002775275,0.0004324521,0.0005138504,0.001031155],"category_scores_gemma":[0.0001699563,0.0002777056,0.0004060843,0.0001991541,0.0003243366,0.0003223053,0.0002012222,0.001555807,0.000290447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002304072,"about_ca_system_score_gemma":0.0004050678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001227102,"about_ca_topic_score_gemma":0.003689151,"domain_scores_codex":[0.9998634,0.00001718914,0.00001872491,0.00002401709,0.00002466388,0.00005204689],"domain_scores_gemma":[0.9997659,0.00001462209,0.00007283661,0.00002872474,0.00002349441,0.00009439702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00243934,0.001248461,0.0002756996,0.0001151809,0.00004547193,0.0001138662,0.00005003239,0.0001056117,0.9886058,0.0001047316,0.0001650929,0.00673062],"study_design_scores_gemma":[0.001423048,0.0302956,0.01826944,0.00006554576,0.0002052224,0.0006725969,0.0002265861,0.001785278,0.9434065,0.0002089751,0.003409263,0.00003205355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974934,0.0006805723,0.0006808676,0.0001226741,0.00005191986,0.00004722432,0.00029939,0.0001517899,0.0004721128],"genre_scores_gemma":[0.9924101,0.001384921,0.001696825,0.0001227629,0.00003759736,0.0001217799,0.0007578726,0.00004243851,0.003425725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001227102,"threshold_uncertainty_score":0.003449559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02170258928122098,"score_gpt":0.277788384003489,"score_spread":0.256085794722268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}