{"id":"W4392110815","doi":"10.3390/biomedicines12030503","title":"Targeting Oral Squamous Cell Carcinoma with Combined Polo-Like-Kinase-1 Inhibitors and γ-Radiation Therapy","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; University of Calgary","funders":"National Institutes of Health; Calgary Foundation","keywords":"Cancer research; Apoptosis; Cell cycle; Polo-like kinase; Kinase; Radiation therapy; Cell growth; Cell; Targeted therapy; Oncogene; Cell cycle checkpoint; Medicine; Biology; Internal medicine; Cancer; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001631369,0.0003677578,0.0005709901,0.0004512068,0.0001183957,0.0004859396,0.0003042685,0.000288506,0.0009300998],"category_scores_gemma":[0.0000753261,0.0001900141,0.0003677287,0.0003088927,0.0001992916,0.0002942499,0.0003049062,0.0006017768,0.0002914229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003302283,"about_ca_system_score_gemma":0.0003404141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005376749,"about_ca_topic_score_gemma":0.00196501,"domain_scores_codex":[0.9999011,0.00001142009,0.000008128962,0.00001948776,0.00002979002,0.00003016119],"domain_scores_gemma":[0.9999691,0.000004667929,0.000008967952,0.000004683567,0.000003608001,0.000009050777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009604237,0.0005313721,0.0005220882,0.0002515379,0.00007710963,0.0001300361,0.00005413505,0.001623808,0.9680207,0.0003089269,0.000202768,0.02731705],"study_design_scores_gemma":[0.0002175795,0.006186588,0.003794455,0.0000279631,0.0001583236,0.00060213,0.00006203376,0.00291642,0.9775415,0.0001249063,0.008351799,0.00001628207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876224,0.007350702,0.001979559,0.0001025158,0.00005384922,0.0001249334,0.0001296581,0.000105059,0.002531419],"genre_scores_gemma":[0.9930194,0.003133548,0.001982299,0.00004376681,0.00001263979,0.00005853011,0.0001502353,0.00001489694,0.00158464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009300998,"threshold_uncertainty_score":0.003111482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005618106698135695,"score_gpt":0.2202182058572241,"score_spread":0.2146000991590884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}