{"id":"W4392110815","doi":"10.3390/biomedicines12030503","title":"Targeting Oral Squamous Cell Carcinoma with Combined Polo-Like-Kinase-1 Inhibitors and γ-Radiation Therapy","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network; University of Calgary","funders":"National Institutes of Health; Calgary Foundation","keywords":"Cancer research; Apoptosis; Cell cycle; Polo-like kinase; Kinase; Radiation therapy; Cell growth; Cell; Targeted therapy; Oncogene; Cell cycle checkpoint; Medicine; Biology; Internal medicine; Cancer; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009685788,0.0001565915,0.0001181025,0.00008179313,0.00006161955,0.00003283744,0.000064937,0.000108375,0.000008664035],"category_scores_gemma":[0.000008264145,0.0001114874,0.00002942818,0.0001319165,0.0001058294,0.000005157255,0.00003104695,0.00006032331,0.000003379888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001011917,"about_ca_system_score_gemma":0.00005430305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009249648,"about_ca_topic_score_gemma":0.00001255014,"domain_scores_codex":[0.9992653,0.00002553123,0.0001396895,0.0002965661,0.00008913213,0.0001837515],"domain_scores_gemma":[0.999711,0.00001247739,0.00003532589,0.0001354039,0.00003661372,0.00006919252],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008934215,0.00004005005,0.01203167,0.00007295535,0.00001928519,0.00001601649,0.0001590882,0.000001779679,0.9671986,0.00001514005,0.01309304,0.007263085],"study_design_scores_gemma":[0.004445468,0.004878924,0.01421977,0.00007509568,0.0001021542,0.00007386754,0.000724648,0.001679199,0.5882333,0.00004122937,0.3847441,0.0007822418],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777503,0.02090497,0.0002273167,0.0003393213,0.0004256635,0.000185813,0.00001397742,0.00003080114,0.0001218446],"genre_scores_gemma":[0.9975995,0.0007349555,0.0001576228,0.0002935751,0.0005034441,0.00001415447,0.0002750415,0.00002910232,0.0003926145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3789653,"threshold_uncertainty_score":0.4546324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005618106698135695,"score_gpt":0.2202182058572241,"score_spread":0.2146000991590884,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}