{"id":"W4392123900","doi":"10.1158/1535-7163.mct-23-0868","title":"Structural Basis for Multivalent MUC16 Recognition and Robust Anti-Pancreatic Cancer Activity of Humanized Antibody AR9.6","year":2024,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; University of Victoria; National Research Council Canada","funders":"National Cancer Institute; National Institute of General Medical Sciences; University of Nebraska-Lincoln; National Institutes of Health; American Cancer Society","keywords":"Antibody; Cancer; Pancreatic cancer; Humanized antibody; Medicine; Humanized mouse; Immunology; Cancer research; Pharmacology; Immune system; Internal medicine; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001243886,0.000209551,0.0004011019,0.0001248006,0.00008662725,0.00003539781,0.0000718934,0.00009735263,0.0002012044],"category_scores_gemma":[0.00001493298,0.0001634751,0.0001729445,0.0001906516,0.0001474313,0.00006444522,0.00003992227,0.0002053266,0.000002377874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009739056,"about_ca_system_score_gemma":0.0001812432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007878574,"about_ca_topic_score_gemma":0.00005744117,"domain_scores_codex":[0.9987608,0.00005835556,0.0002169874,0.0003457302,0.0003147346,0.0003033789],"domain_scores_gemma":[0.9993701,0.0001189744,0.00006084102,0.0001628015,0.0001920659,0.0000952156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007829067,0.00006019167,0.004618997,0.001823928,0.001021683,0.00003486343,0.0004278352,0.00004451754,0.8603278,0.00008507571,0.00002787301,0.1307443],"study_design_scores_gemma":[0.003172196,0.0007950399,0.06855851,0.002293762,0.001983957,0.00006460706,0.0001516479,0.05530383,0.8598937,0.0009306096,0.006218348,0.0006338039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779227,0.01747515,0.001493247,0.001527823,0.0002259188,0.0007130606,0.0005018156,0.00004049044,0.00009978022],"genre_scores_gemma":[0.9912871,0.006481012,0.001009884,0.0003393665,0.0001680198,0.0001128019,0.00007553348,0.00004929268,0.0004769749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1301105,"threshold_uncertainty_score":0.6666319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1018651371166224,"score_gpt":0.3861322694136576,"score_spread":0.2842671322970353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}