{"id":"W4392125982","doi":"10.1093/oncolo/oyae019","title":"Extended Safety and Tolerability of Darolutamide for Nonmetastatic Castration-Resistant Prostate Cancer and Adverse Event Time Course in ARAMIS","year":2024,"lang":"en","type":"article","venue":"The Oncologist","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Health Sciences Centre; Sunnybrook Health Science Centre","funders":"Bayer HealthCare; Bayer","keywords":"Tolerability; Medicine; Adverse effect; Placebo; Prostate cancer; Internal medicine; Androgen deprivation therapy; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007033068,0.0001006128,0.0002720355,0.00003923166,0.00006007532,0.00001271506,0.00003831745,0.0000361302,0.00004422649],"category_scores_gemma":[0.00006811148,0.00005803084,0.00003938013,0.0001212725,0.0004268638,0.00004779621,0.00002940429,0.0001146963,0.000001727046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002319153,"about_ca_system_score_gemma":0.0004565396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003881702,"about_ca_topic_score_gemma":0.0005471714,"domain_scores_codex":[0.9991328,0.00005839115,0.000271271,0.0002164776,0.0001349265,0.0001861272],"domain_scores_gemma":[0.9993789,0.0003153353,0.00004921082,0.0001410175,0.00005350336,0.0000620641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.07465139,0.004070791,0.09188531,0.01278977,0.002434722,0.001219769,0.02165874,0.001399145,0.146069,0.00352316,0.00447715,0.635821],"study_design_scores_gemma":[0.01225639,0.004663321,0.9330398,0.001205512,0.0009372635,0.00006827616,0.002570739,0.02794075,0.004791823,0.003320693,0.008856457,0.0003489167],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983877,0.006014505,0.00002657226,0.007487451,0.00005729913,0.001834439,0.0003334225,0.00001923501,0.0003500867],"genre_scores_gemma":[0.9954763,0.001313626,0.0002316452,0.00004485637,0.00002395164,0.00018763,0.00002998967,0.000009845172,0.002682136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8411546,"threshold_uncertainty_score":0.2366429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02509620189157084,"score_gpt":0.3702472411746977,"score_spread":0.3451510392831268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}