{"id":"W4392126042","doi":"10.1016/j.clgc.2024.02.011","title":"Association of Cabozantinib Dose Reductions for Toxicity With Clinical Effectiveness in Metastatic Renal Cell Carcinoma (mRCC): Results From the Canadian Kidney Cancer Information System (CKCis)","year":2024,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Centre hospitalier universitaire de Québec; Centre Hospitalier de l’Université de Montréal; Centre hospitalier de l'Université Laval; University of Calgary; Princess Margaret Cancer Centre; University of Toronto; Health Sciences Centre; CancerCare Manitoba; University Health Network; McMaster University Medical Centre; Hôtel-Dieu de Québec; McGill University; University of Ottawa; University of Alberta; Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Cabozantinib; Medicine; Renal cell carcinoma; Toxicity; Tyrosine-kinase inhibitor; Kidney cancer; Oncology; Drug; Cancer; Internal medicine; Clinical trial; Tyrosine kinase; Pharmacology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00266041,0.0002830726,0.0008172408,0.0001826393,0.0001579564,0.0000594801,0.0001801539,0.0002828065,0.00003436219],"category_scores_gemma":[0.0008713373,0.0001882745,0.0003975443,0.0005426207,0.0001535509,0.0002358361,0.00004232337,0.0007009454,0.00001736485],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001991184,"about_ca_system_score_gemma":0.004944033,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1141313,"about_ca_topic_score_gemma":0.06529331,"domain_scores_codex":[0.9961334,0.0007294559,0.001682775,0.000549573,0.0004693592,0.0004354139],"domain_scores_gemma":[0.9950402,0.003000469,0.000517366,0.0005054671,0.0004571927,0.0004793383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01793658,0.0007821802,0.916006,0.002452935,0.002120116,0.0004622057,0.001457764,0.001496266,0.000617277,0.00005990203,0.04016031,0.01644849],"study_design_scores_gemma":[0.009926167,0.001650971,0.9625926,0.001689543,0.001859913,0.00001906533,0.0004010781,0.00236251,0.003239389,0.0000192276,0.01595998,0.0002795776],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870321,0.001089067,0.00004625964,0.003686887,0.00202407,0.002236509,0.00307714,0.00004856243,0.0007593608],"genre_scores_gemma":[0.9961736,0.0002334672,0.0005055954,0.000336319,0.001173278,0.0007089548,0.0004050151,0.00003715944,0.0004266006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.048838,"threshold_uncertainty_score":0.9517627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05938976335606583,"score_gpt":0.3627307047599025,"score_spread":0.3033409414038367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}