{"id":"W4392126042","doi":"10.1016/j.clgc.2024.02.011","title":"Association of Cabozantinib Dose Reductions for Toxicity With Clinical Effectiveness in Metastatic Renal Cell Carcinoma (mRCC): Results From the Canadian Kidney Cancer Information System (CKCis)","year":2024,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Centre hospitalier universitaire de Québec; Centre Hospitalier de l’Université de Montréal; Centre hospitalier de l'Université Laval; University of Calgary; Princess Margaret Cancer Centre; University of Toronto; Health Sciences Centre; CancerCare Manitoba; University Health Network; McMaster University Medical Centre; Hôtel-Dieu de Québec; McGill University; University of Ottawa; University of Alberta; Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Cabozantinib; Medicine; Renal cell carcinoma; Toxicity; Tyrosine-kinase inhibitor; Kidney cancer; Oncology; Drug; Cancer; Internal medicine; Clinical trial; Tyrosine kinase; Pharmacology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003186183,0.0003660666,0.0009417767,0.0008942403,0.0003299086,0.0007379766,0.0007161648,0.0004561896,0.003063111],"category_scores_gemma":[0.01132039,0.0001504761,0.00241957,0.002003643,0.0002503282,0.0003997453,0.0003601072,0.0008729409,0.0002216857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00537093,"about_ca_system_score_gemma":0.005371888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3931789,"about_ca_topic_score_gemma":0.5357152,"domain_scores_codex":[0.9977264,0.0005120383,0.0002154749,0.0003144076,0.001009667,0.0002220333],"domain_scores_gemma":[0.9917652,0.003401648,0.002619871,0.0003880818,0.001153308,0.0006718036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03243146,0.0001951907,0.902742,0.0006359944,0.00607516,0.00004247682,0.00009425917,0.002189857,0.0005838005,0.0001528946,0.006992349,0.04786463],"study_design_scores_gemma":[0.00042036,0.0007762008,0.9938576,0.0000401645,0.001977655,0.0000383527,0.0000324773,0.0008488105,0.0001855674,0.00005127955,0.001753864,0.00001776943],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9297544,0.01890349,0.0003948203,0.001593065,0.00005876522,0.0001583961,0.04001429,0.0001140672,0.009008721],"genre_scores_gemma":[0.9876921,0.001524646,0.0002927313,0.0002455936,0.00003550313,0.00002469053,0.009244585,0.00002028661,0.0009198354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3931789,"threshold_uncertainty_score":0.7817808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05938976335606583,"score_gpt":0.3627307047599025,"score_spread":0.3033409414038367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}