{"id":"W4392131843","doi":"10.1111/apha.14119","title":"<scp>MFN2</scp> overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and <scp>H<sub>2</sub>O<sub>2</sub></scp> emission","year":2024,"lang":"en","type":"article","venue":"Acta Physiologica","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université du Québec à Trois-Rivières; McGill University; Université du Québec à Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"MFN2; mitochondrial fusion; Sarcopenia; Muscle hypertrophy; Skeletal muscle; Mitochondrion; Biology; Endocrinology; Cell biology; Fibrosis; Internal medicine; Chemistry; Medicine; Mitochondrial DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001610728,0.0004134334,0.0004575329,0.000171789,0.0001541201,0.00007589188,0.0001781677,0.000542948,0.00000223259],"category_scores_gemma":[0.0006494719,0.0003441134,0.0001410462,0.0002073132,0.0002089913,0.00004537316,0.0003232697,0.0003337996,0.000005541453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002208734,"about_ca_system_score_gemma":0.00006294223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002624541,"about_ca_topic_score_gemma":0.00001916549,"domain_scores_codex":[0.9975921,0.0002829334,0.0004913707,0.0009974667,0.0001982975,0.0004378151],"domain_scores_gemma":[0.9989624,0.0002163983,0.0002042908,0.0003802537,0.00007829283,0.0001583693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001056327,0.00008354981,0.0005011609,0.0001650741,0.0000439146,0.00001378976,0.0002631559,0.00003151471,0.9946966,0.0000199507,0.002598702,0.001477008],"study_design_scores_gemma":[0.0008825476,0.0008945067,0.006154796,0.0003287065,0.00003964377,0.00004812262,0.0001854556,0.0002520153,0.9861518,0.0001678226,0.00476183,0.0001328156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969333,0.001620741,0.00009932686,0.00003121143,0.0005485502,0.0004433604,0.00005772206,0.00005664697,0.0002090762],"genre_scores_gemma":[0.9962804,0.002004148,0.0002911212,0.0002196005,0.000813504,0.00006756066,0.0001994123,0.00004790389,0.00007629325],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008544809,"threshold_uncertainty_score":0.9999011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286194287436543,"score_gpt":0.2373852944924219,"score_spread":0.2245233516180565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}