{"id":"W4392131843","doi":"10.1111/apha.14119","title":"<scp>MFN2</scp> overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and <scp>H<sub>2</sub>O<sub>2</sub></scp> emission","year":2024,"lang":"en","type":"article","venue":"Acta Physiologica","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université du Québec à Trois-Rivières; McGill University; Université du Québec à Montréal","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada","keywords":"MFN2; mitochondrial fusion; Sarcopenia; Muscle hypertrophy; Skeletal muscle; Mitochondrion; Biology; Endocrinology; Cell biology; Fibrosis; Internal medicine; Chemistry; Medicine; Mitochondrial DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002406482,0.0007200663,0.0003839596,0.0006500896,0.0002668806,0.0002803133,0.0002531334,0.0007037307,0.002370597],"category_scores_gemma":[0.00009423831,0.0003241734,0.0004937563,0.0002059118,0.0006109206,0.0003869802,0.0002477669,0.0009814047,0.0004695851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003551025,"about_ca_system_score_gemma":0.0001903632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009362168,"about_ca_topic_score_gemma":0.001513973,"domain_scores_codex":[0.9997523,0.00002316466,0.00003644454,0.00007700909,0.00005071399,0.00006021643],"domain_scores_gemma":[0.9996536,0.0000256975,0.0001331234,0.00002345465,0.00002687353,0.0001372039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001880788,0.00002867178,0.0001624627,0.00002587371,0.000004775149,0.00004021199,0.0000112799,0.00002117886,0.999191,0.00003639464,0.00003657494,0.0002534346],"study_design_scores_gemma":[0.00004565379,0.00067141,0.01714308,0.00002155964,0.00004115694,0.0003435669,0.00008943718,0.0007274226,0.9785468,0.0000589098,0.00229772,0.00001334587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920405,0.001086204,0.003117143,0.0001693985,0.0000817139,0.00005185786,0.002012535,0.0001907407,0.001249879],"genre_scores_gemma":[0.9795629,0.001063721,0.004589647,0.0002079717,0.00003949876,0.0002549837,0.002411989,0.0001386324,0.01173079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002370597,"threshold_uncertainty_score":0.007930458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286194287436543,"score_gpt":0.2373852944924219,"score_spread":0.2245233516180565,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}