{"id":"W4392137584","doi":"10.1021/acs.jmedchem.3c01532","title":"Toward a Template for Synthetic Actin-Targeting Macrolide Analogues That Inhibit Cancer Cell Invasiveness","year":2024,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Extracellular matrix; A549 cell; Cancer cell; Actin; Cancer; Substituent; Extracellular; Motility; Cell; Biochemistry; Cancer research; Cell biology; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001453138,0.0004554429,0.0008033158,0.00004970638,0.0001078346,0.0001108396,0.0006679627,0.000380465,0.00451151],"category_scores_gemma":[0.001072799,0.0003845365,0.0004969839,0.0001808519,0.0001751578,0.0002054736,0.0001109234,0.0009484934,0.000005519927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006170021,"about_ca_system_score_gemma":0.0007576044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003907386,"about_ca_topic_score_gemma":0.000001862296,"domain_scores_codex":[0.9970117,0.000036364,0.001028944,0.0004986852,0.0008323562,0.0005919884],"domain_scores_gemma":[0.9968339,0.001427919,0.0007025463,0.0003475155,0.0002850506,0.0004030244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002186248,0.00007446594,0.0002231864,0.006716137,0.0002593822,0.0005045463,0.0006720049,0.00001767333,0.9799642,0.000001409251,0.004187167,0.00716118],"study_design_scores_gemma":[0.0009285426,0.00002985629,0.000005242867,0.003209498,0.0005349276,0.00206645,0.003262143,0.0002049499,0.9616967,0.0002724727,0.02741646,0.0003727704],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9446767,0.03582017,0.003354492,0.002604029,0.001328184,0.0001359672,0.0001582436,0.0001601458,0.01176208],"genre_scores_gemma":[0.9904531,0.001282516,0.002968916,0.0000801491,0.003104835,0.00002715501,0.00001722601,0.0001146948,0.001951428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0457764,"threshold_uncertainty_score":0.9998606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04933120144472932,"score_gpt":0.321162554477682,"score_spread":0.2718313530329527,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}