{"id":"W4392137921","doi":"10.1007/s00253-024-13033-5","title":"Outer membrane vesicles as a platform for the discovery of antibodies to bacterial pathogens","year":2024,"lang":"en","type":"review","venue":"Applied Microbiology and Biotechnology","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; National Research Council Canada","funders":"National Research Council Canada","keywords":"Bacterial outer membrane; Periplasmic space; Bacteria; Microbiology; Antigen; Biology; Bacterial cell structure; Vesicle; Antibody; Gram-negative bacteria; Antimicrobial; Chemistry; Escherichia coli; Membrane; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0002617371,0.0005879378,0.001815649,0.0004185307,0.0002568919,0.00003756558,0.0004697676,0.0024634,0.00006217058],"category_scores_gemma":[0.00004982324,0.0003320713,0.0003973977,0.0002776138,0.0007484891,0.00003888806,0.0005600353,0.0005912876,0.0002728749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002678769,"about_ca_system_score_gemma":0.0001138211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003240478,"about_ca_topic_score_gemma":0.00005315519,"domain_scores_codex":[0.9979436,0.00005412437,0.0007415172,0.0007363012,0.000006858969,0.0005176292],"domain_scores_gemma":[0.998655,0.0004735702,0.0002911246,0.0005268769,0.00003678745,0.00001664203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001426182,0.00003427827,1.91117e-7,0.001669584,0.001070868,0.000001198161,0.00004739691,2.065956e-8,0.6996778,0.01232917,0.001597765,0.2834291],"study_design_scores_gemma":[0.0003675118,0.0003091042,7.062771e-7,0.0005646298,0.001601609,0.0007171878,0.00006950594,2.099504e-8,0.09324826,0.0002495762,0.902533,0.0003388929],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0141553,0.9782703,0.00009360143,0.0005508831,0.002794065,0.001949436,0.001994579,0.0001482484,0.00004360509],"genre_scores_gemma":[0.004612517,0.9929296,0.0001166764,0.00007715817,0.0002276503,0.0004570071,0.0008927984,0.00005921956,0.0006273732],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9009352,"threshold_uncertainty_score":0.9999132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02137861498673327,"score_gpt":0.2736508362600769,"score_spread":0.2522722212733436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}