{"id":"W4392157091","doi":"10.1016/j.celrep.2024.113826","title":"The genomic and evolutionary landscapes of anaplastic thyroid carcinoma","year":2024,"lang":"en","type":"article","venue":"Cell Reports","topic":"Thyroid Cancer Diagnosis and Treatment","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Cancer Care Ontario; Hospital for Sick Children; University of Saskatchewan; Western University; University of Toronto; BC Cancer Agency; Ontario Institute for Cancer Research; Lawson Health Research Institute; McMaster University","funders":"National Cancer Institute; Jonsson Comprehensive Cancer Center; Canadian Institutes of Health Research; University of Texas MD Anderson Cancer Center; Physicians' Services Incorporated Foundation; Ontario Genomics Institute; Government of Canada; London Health Sciences Foundation; Government of Ontario; Florida Department of Health; Instituto Tecnológico de Costa Rica; Mayo Foundation for Medical Education and Research; Genome Canada; National Institutes of Health; Ontario Genomics; Mayo Clinic","keywords":"Anaplastic thyroid cancer; Thyroid carcinoma; Thyroid cancer; Thyroid; Malignancy; Cancer research; Biology; Cancer; Pathology; Medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007172779,0.00007281284,0.0001190158,0.00003324033,0.00005263596,0.00001432729,0.00001587754,0.0000259635,0.00002409473],"category_scores_gemma":[0.00001272007,0.00004320772,0.00005340266,0.00005839405,0.00004135384,0.00001780125,0.00002375911,0.00005236386,0.000005378528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005037967,"about_ca_system_score_gemma":0.0001215765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003788183,"about_ca_topic_score_gemma":0.00001326401,"domain_scores_codex":[0.9994221,0.000007747582,0.0001848556,0.000174025,0.0001072749,0.000104018],"domain_scores_gemma":[0.9995834,0.0001016029,0.00004606257,0.0001883063,0.00002344911,0.0000572262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002286073,0.0003491312,0.8618472,0.0009098011,0.000400799,0.009709547,0.0008281153,0.00006568765,0.03794535,0.0007431785,0.07029141,0.01668121],"study_design_scores_gemma":[0.0003945793,0.0005782169,0.9207841,0.0001231541,0.0003045779,0.001679889,0.0001180649,0.0002872564,0.008604783,0.0005706167,0.06645766,0.00009714429],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8804173,0.1150698,0.000003508806,0.0003003064,0.0002555477,0.0001390729,0.000003407983,0.00002182801,0.003789123],"genre_scores_gemma":[0.9969281,0.001849529,0.00003830386,0.0000164234,0.00009259638,0.00002329751,0.000008976531,0.00001113743,0.001031647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1165107,"threshold_uncertainty_score":0.176196,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006780527691733478,"score_gpt":0.2232148015300301,"score_spread":0.2164342738382966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}