{"id":"W4392159460","doi":"10.1038/s41525-024-00397-w","title":"DNA and RNA base editors can correct the majority of pathogenic single nucleotide variants","year":2024,"lang":"en","type":"article","venue":"npj Genomic Medicine","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Israel Science Foundation; National Institutes of Health; Foundation Fighting Blindness","keywords":"Genetics; RNA; DNA; Nucleotide; Base (topology); Biology; Computational biology; Base pair; Gene; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001414342,0.0007339414,0.0008498848,0.0008223174,0.000533492,0.001660488,0.0006388531,0.001185314,0.004777455],"category_scores_gemma":[0.00365916,0.0003330225,0.0005314684,0.00045412,0.0006174734,0.00116994,0.0007158062,0.001171842,0.002353956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003429918,"about_ca_system_score_gemma":0.0004260178,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003051202,"about_ca_topic_score_gemma":0.0006343298,"domain_scores_codex":[0.9984614,0.0002840743,0.0001061256,0.0003694284,0.0006755826,0.0001033866],"domain_scores_gemma":[0.9986508,0.0004737514,0.0003708279,0.0002329467,0.0001921956,0.00007945878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003163201,0.00008470144,0.001542327,0.00063237,0.0000835269,0.0004982112,0.00008721431,0.001398591,0.8864319,0.003365058,0.00174759,0.1038123],"study_design_scores_gemma":[0.00004181625,0.0008296923,0.00286346,0.00008890571,0.0001669579,0.002033837,0.00008097134,0.003750506,0.9067723,0.003066697,0.08024523,0.00005964733],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5998822,0.1148826,0.2150311,0.002998867,0.003237107,0.0005123914,0.003348453,0.005870713,0.05423663],"genre_scores_gemma":[0.8757349,0.02653053,0.07834788,0.00115549,0.0005347246,0.0002128926,0.002568467,0.0007517905,0.01416348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004777455,"threshold_uncertainty_score":0.01598221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007698780476835962,"score_gpt":0.2523281545169749,"score_spread":0.244629374040139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}