{"id":"W4392166798","doi":"10.3390/biology13030146","title":"ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor","year":2024,"lang":"en","type":"review","venue":"Biology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Canadian Foundation for AIDS Research","keywords":"Biology; ATF4; Autophagy; Transcription factor; Viral replication; Signal transduction; Unfolded protein response; Innate immune system; Virology; Virus; Immunology; Cell biology; Apoptosis; Immune system; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002075818,0.0006425189,0.0007113506,0.001163469,0.0002113714,0.0005928354,0.0005093859,0.0006964324,0.002568087],"category_scores_gemma":[0.0001945047,0.0001623988,0.0003033821,0.001207469,0.0002328269,0.0007873961,0.0004619417,0.001276925,0.002055919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004257298,"about_ca_system_score_gemma":0.0005890774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005106578,"about_ca_topic_score_gemma":0.0008522077,"domain_scores_codex":[0.9999338,0.00001034075,0.00001008635,0.00001205747,0.00002414763,0.000009483677],"domain_scores_gemma":[0.9999316,0.00002170675,0.00001093846,0.00000246112,0.00002159986,0.00001171864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001095461,0.0000661598,0.0001487918,0.01147381,0.00006115357,0.0002243846,0.00004971138,0.0003165897,0.004985098,0.002477607,0.03375181,0.9463354],"study_design_scores_gemma":[0.00001312518,0.0001269836,0.0009308438,0.001706678,0.00007404939,0.001495971,0.00004274552,0.00008631447,0.001144056,0.00127614,0.9930891,0.0000139162],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002289067,0.9978181,0.0001350841,0.0002388061,0.0003509878,0.000004333187,0.0000211381,0.00001031641,0.001192382],"genre_scores_gemma":[0.0008371058,0.9977422,0.0001521207,0.0001683935,0.000193263,0.000005732269,0.00003844247,0.000001580759,0.0008611957],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002568087,"threshold_uncertainty_score":0.008591115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05703021380550569,"score_gpt":0.3523625176566483,"score_spread":0.2953323038511426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}