{"id":"W4392168382","doi":"10.3390/ijms25052676","title":"Molecular Behavior of α-Synuclein Is Associated with Membrane Transport, Lipid Metabolism, and Ubiquitin–Proteasome Pathways in Lewy Body Disease","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; University Health Network; Toronto Western Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"University of Toronto; Edmond J. Safra Philanthropic Foundation","keywords":"Lewy body; Ubiquitin; Proteasome; Alpha-synuclein; Lipid metabolism; Cell biology; Synuclein; Parkinson's disease; Chemistry; Transport protein; Disease; Biology; Biochemistry; Medicine; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001231511,0.0002135951,0.0002015471,0.0005746728,0.0002448364,0.0003569341,0.00008541554,0.000224331,0.0004044376],"category_scores_gemma":[0.0001394196,0.0001282801,0.0002333382,0.0004204149,0.000256655,0.0002210795,0.0001803782,0.0001709331,0.0001363402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044342,"about_ca_system_score_gemma":0.0001539474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001033834,"about_ca_topic_score_gemma":0.001734245,"domain_scores_codex":[0.9998933,0.00001007609,0.00001050023,0.00003414837,0.00003495171,0.00001699539],"domain_scores_gemma":[0.999904,0.00001334674,0.00003895916,0.000008696354,0.00002111295,0.00001386024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001171812,0.00001310289,0.02651375,0.00005875263,0.00002837712,0.0001861361,0.00008631145,0.0001075351,0.9704565,0.00004633249,0.000038034,0.002347966],"study_design_scores_gemma":[0.000004612048,0.000130408,0.8554678,0.00001684294,0.00009060217,0.001170507,0.0003528697,0.00158301,0.1398593,0.0002548483,0.001058484,0.00001080239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978997,0.0007192387,0.0007515918,0.00001883324,0.000002554686,0.000005761797,0.0002816569,0.00002066904,0.0002999799],"genre_scores_gemma":[0.9971476,0.0005501215,0.001027982,0.0000308094,0.000002582329,0.00001665759,0.0005384014,0.000005823088,0.0006799929],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001033834,"threshold_uncertainty_score":0.002055645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01459584646237021,"score_gpt":0.2727672594200634,"score_spread":0.2581714129576931,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}