{"id":"W4392185185","doi":"10.1086/730186","title":"Conditionally Deleterious Mutation Load Accumulates in Genomic Islands of Local Adaptation but Can Be Purged with Sufficient Genotypic Redundancy","year":2024,"lang":"en","type":"article","venue":"The American Naturalist","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Mount Royal University","funders":"","keywords":"Biology; Local adaptation; Maladaptation; Genetics; Locus (genetics); Balancing selection; Adaptation (eye); Allele; Redundancy (engineering); Phenotype; Genotype; Genetic load; Evolutionary biology; Population; Gene; Computer science; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003810108,0.0002266203,0.000538948,0.0002514585,0.0004249148,0.0005703573,0.000532515,0.0003581858,0.001791545],"category_scores_gemma":[0.001932907,0.0002114976,0.0002582784,0.0001772305,0.0008108686,0.000630233,0.0006564929,0.0006945044,0.000165786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004896998,"about_ca_system_score_gemma":0.0005240269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001652197,"about_ca_topic_score_gemma":0.002254614,"domain_scores_codex":[0.9998584,0.00003060618,0.00000829089,0.00003389973,0.00002597607,0.00004273737],"domain_scores_gemma":[0.9993075,0.0002477462,0.0001107561,0.0001342142,0.00006209422,0.000137612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0005897857,0.000463675,0.0395369,0.0003153925,0.0004031086,0.001217534,0.0003963858,0.6318575,0.2891727,0.01677409,0.001287932,0.01798493],"study_design_scores_gemma":[0.00009750277,0.0004355421,0.02010424,0.00002318413,0.0001090407,0.0002727924,0.0002307051,0.9420384,0.02673961,0.008712193,0.001183903,0.00005290341],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960825,0.00003844816,0.003045527,0.00005802151,0.000008666712,0.000004430045,0.00001840453,0.00005579964,0.0006880733],"genre_scores_gemma":[0.9990055,0.00001835575,0.0007620858,0.00001782235,0.000001463093,0.000006937785,0.00001808348,0.00001239767,0.0001574777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001791545,"threshold_uncertainty_score":0.005993307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007321999024247408,"score_gpt":0.2491565300304507,"score_spread":0.2418345310062033,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}