{"id":"W4392190178","doi":"10.1101/2024.02.22.579698","title":"Loss of the APP regulator RHBDL4 preserves memory in an Alzheimer’s disease mouse model","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McGill University","funders":"Lady Davis Institute for Medical Research; Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Alzheimer Society; Scottish Rite Charitable Foundation of Canada; McGill University; Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Regulator; Neuroscience; Disease; Alzheimer's disease; Psychology; Computer science; Medicine; Biology; Internal medicine; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002958028,0.0009720803,0.0006450717,0.001135996,0.0003271832,0.0005414124,0.0005815482,0.0008151791,0.002260114],"category_scores_gemma":[0.000207401,0.0003832973,0.0006320643,0.0003620683,0.0005578394,0.0004451174,0.0003104045,0.001384612,0.001634053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004082514,"about_ca_system_score_gemma":0.0002718289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008257594,"about_ca_topic_score_gemma":0.0008040318,"domain_scores_codex":[0.9996234,0.00004131539,0.00004908083,0.00009577293,0.00008838908,0.0001019363],"domain_scores_gemma":[0.9995598,0.00003516972,0.0001402229,0.00008576783,0.0000635148,0.0001154686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003498411,0.00005687779,0.00009868624,0.00003230705,0.000009546221,0.00008421011,0.00001261998,0.00003472131,0.9985392,0.00005449296,0.0000528753,0.0006746817],"study_design_scores_gemma":[0.0000711492,0.0005230424,0.002478212,0.00001246489,0.00005209841,0.0003364447,0.00004915893,0.0005077228,0.993432,0.00008693704,0.002439175,0.00001163983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873159,0.00190251,0.00561175,0.00031142,0.0001236969,0.00006492573,0.002506936,0.0006373291,0.001525596],"genre_scores_gemma":[0.9832571,0.001150698,0.004078815,0.0001667685,0.00003994105,0.0002011221,0.002579872,0.0002370898,0.008288658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002260114,"threshold_uncertainty_score":0.007560849,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03309495713285881,"score_gpt":0.2842905594740568,"score_spread":0.251195602341198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}