{"id":"W4392190620","doi":"10.3233/jad-230883","title":"Cholinergic Receptor Muscarinic 1 Co-Localized with Mitochondria in Cultured Dorsal Root Ganglion Neurons, and Its Deletion Disrupted Mitochondrial Ultrastructure in Peripheral Neurons: Implications in Alzheimer’s Disease","year":2024,"lang":"en","type":"article","venue":"Journal of Alzheimer s Disease","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Ultrastructure; Muscarinic acetylcholine receptor; Dorsal root ganglion; Cholinergic; Mitochondrion; Neuroscience; Biology; Peripheral; Ganglion; Cholinergic neuron; Cell biology; Anatomy; Dorsum; Receptor; Medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003102601,0.0003431078,0.0004429108,0.0003472429,0.0003180802,0.0004492281,0.0005436593,0.0004040836,0.000803027],"category_scores_gemma":[0.0001296447,0.000190735,0.0003249414,0.0003798078,0.0002947857,0.0002984614,0.0003022363,0.0007360094,0.0006022471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007959324,"about_ca_system_score_gemma":0.000346801,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002883753,"about_ca_topic_score_gemma":0.004642157,"domain_scores_codex":[0.9996405,0.00002118313,0.00003952702,0.0001041615,0.000126423,0.00006819946],"domain_scores_gemma":[0.9997686,0.00003746637,0.00005911366,0.000037078,0.00004853763,0.00004925688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003389236,0.000012333,0.0002814086,0.00003763748,0.000004976481,0.00005677694,0.00002301872,0.00001695197,0.9991156,0.00002546868,0.00001747885,0.0003742515],"study_design_scores_gemma":[0.00001724869,0.0002091994,0.02404716,0.00002618433,0.00004882257,0.0008199262,0.0001675557,0.00111796,0.9720518,0.00005418182,0.001433039,0.000006901649],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871736,0.004260434,0.00561934,0.0001587903,0.00006651009,0.00003028915,0.0006273291,0.00008887852,0.001974917],"genre_scores_gemma":[0.9856418,0.002021679,0.007786723,0.00005707286,0.00001551368,0.00005724948,0.0009870309,0.0000319295,0.003400997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002883753,"threshold_uncertainty_score":0.005774915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02172152356366613,"score_gpt":0.3200554464225432,"score_spread":0.2983339228588771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}