{"id":"W4392200032","doi":"10.1186/s12915-024-01845-w","title":"Primary cilia promote the differentiation of human neurons through the WNT signaling pathway","year":2024,"lang":"en","type":"article","venue":"BMC Biology","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Artificial Intelligence in Medicine (Canada)","funders":"O. E. och Edla Johanssons Vetenskapliga Stiftelse; Sigrid Juséliuksen Säätiö; Åhlén-stiftelsen; Vetenskapsrådet; Stiftelsen för Strategisk Forskning; Fredrik och Ingrid Thurings Stiftelse; Stiftelsen Olle Engkvist Byggmästare; Novo Nordisk; Stiftelsen för Strategisk Forskning; Hjärnfonden; Japan Society for the Promotion of Science; Novo Nordisk Fonden; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden; Karolinska Institutet; Torsten Söderbergs Stiftelse","keywords":"Biology; Cilium; Wnt signaling pathway; Cell biology; Signal transduction; Primary (astronomy); Cellular differentiation; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001081717,0.0002499922,0.0001946846,0.0002167283,0.0001843495,0.0002684808,0.000115769,0.0002196066,0.002571719],"category_scores_gemma":[0.0001193565,0.0001322337,0.0002917603,0.0001383816,0.0001243904,0.00009391044,0.0002658729,0.0002643616,0.000771072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003821329,"about_ca_system_score_gemma":0.0004151382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003970863,"about_ca_topic_score_gemma":0.005665007,"domain_scores_codex":[0.9998879,0.000008260016,0.00001239134,0.00001800451,0.00004377949,0.00002969405],"domain_scores_gemma":[0.9999446,0.000008329703,0.00001404143,0.000006507106,0.00001300039,0.00001352761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001014019,0.00001377255,0.0004758435,0.00007169561,0.000006666402,0.00009734258,0.00002066933,0.00003991329,0.9971528,0.00009780263,0.0001470017,0.001775039],"study_design_scores_gemma":[0.00002065508,0.0001542981,0.01639494,0.00002455786,0.00003787604,0.0003684974,0.00004184259,0.0005443214,0.9740467,0.00006963806,0.008293292,0.000003409393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818465,0.005975766,0.002704948,0.0002397886,0.00006311371,0.00007773439,0.00197468,0.0002346919,0.006882831],"genre_scores_gemma":[0.9870685,0.00283111,0.002060086,0.00006472593,0.000007750068,0.00003970512,0.001242783,0.00003253197,0.006652785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003970863,"threshold_uncertainty_score":0.008603275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01902948061064889,"score_gpt":0.2637353516518754,"score_spread":0.2447058710412265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}