{"id":"W4392201179","doi":"10.1101/2024.02.21.581404","title":"<sub>Metabolic</sub> shift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Epigenetics; DNA methylation; Lipid metabolism; Reprogramming; Glutamine; Biology; Carcinogenesis; Glutathione; Cell biology; Biochemistry; Chemistry; Gene; Gene expression; Amino acid; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007837456,0.0002269401,0.0001528072,0.000217019,0.0001114349,0.0002424475,0.0001099089,0.0001318486,0.004447814],"category_scores_gemma":[0.00006562828,0.00008709376,0.0001714772,0.0001948029,0.0001298285,0.00009626181,0.0001960297,0.0003297397,0.0008964882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000224873,"about_ca_system_score_gemma":0.0001550505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000827734,"about_ca_topic_score_gemma":0.0008599127,"domain_scores_codex":[0.9999244,0.00001199465,0.000006644774,0.00001464044,0.00002372457,0.00001850907],"domain_scores_gemma":[0.9999419,0.00001119614,0.00001202323,0.00001334469,0.000006837031,0.00001462613],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000107139,0.00001151397,0.0002790825,0.00001407995,0.000002586884,0.00005182499,0.000008298137,0.00002401461,0.9986531,0.00009035027,0.00005720202,0.0007008034],"study_design_scores_gemma":[0.000006570792,0.00008629606,0.00966012,0.000002916481,0.000005864131,0.0002336565,0.00002881632,0.0002931324,0.9870408,0.00006608728,0.002573671,0.000001997224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989214,0.0009325795,0.002274936,0.0002216741,0.00006709269,0.00001818347,0.002473042,0.0001639063,0.004634641],"genre_scores_gemma":[0.9853449,0.0005472298,0.001432324,0.00007257969,0.00001275893,0.00002095732,0.003126988,0.00005043223,0.009391866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004447814,"threshold_uncertainty_score":0.01487941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008995843603315635,"score_gpt":0.2083864229425434,"score_spread":0.1993905793392278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}