{"id":"W4392207533","doi":"10.2139/ssrn.4739397","title":"Spermidine Suppresses Dc Activation Via Eif5a Hypusination and Metabolic Adaptation","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Spermidine; Adaptation (eye); Chemistry; Cell biology; Biology; Biochemistry; Neuroscience; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000108288,0.0003672291,0.0003544033,0.0002155088,0.0001579971,0.000416225,0.0003056407,0.00035278,0.005775406],"category_scores_gemma":[0.0001729132,0.0001513433,0.0002636525,0.0001901115,0.0002072462,0.0001906791,0.0003228936,0.0006585352,0.0008941145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002798735,"about_ca_system_score_gemma":0.0002150113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00060207,"about_ca_topic_score_gemma":0.0008870875,"domain_scores_codex":[0.999842,0.00002212254,0.00001803561,0.00004392573,0.00003058292,0.00004325678],"domain_scores_gemma":[0.9998048,0.00003898494,0.00004609637,0.00004063764,0.00001995608,0.0000495341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004231896,0.0000223894,0.00007825339,0.00003194096,0.000005223566,0.00004347377,0.000006111034,0.00002246293,0.998113,0.0001106075,0.00007361946,0.00106964],"study_design_scores_gemma":[0.00001559997,0.0001066372,0.001835496,0.000002605494,0.000007490519,0.00005442195,0.00001136391,0.0002139567,0.9960091,0.00003537507,0.00170526,0.000002697325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882483,0.002234147,0.002072192,0.0003216937,0.0002507571,0.00003107117,0.001403464,0.0003534075,0.005084815],"genre_scores_gemma":[0.9902085,0.0005884343,0.001233891,0.00009893927,0.00004032605,0.00002284666,0.0009436693,0.0001049083,0.006758497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005775406,"threshold_uncertainty_score":0.01932061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008756824063294153,"score_gpt":0.2546974158248761,"score_spread":0.245940591761582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}