{"id":"W4392231567","doi":"10.1016/j.joca.2024.02.656","title":"Evolution and advancements in genomics and epigenomics in OA research: How far we have come","year":2024,"lang":"en","type":"review","venue":"Osteoarthritis and Cartilage","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Research Canada; Western University; Ontario Institute for Cancer Research","funders":"Center for International Business Education and Research, University of Illinois at Urbana-Champaign; Instituto de Salud Carlos III; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Horizon 2020; Medical Research Council; Versus Arthritis; National Science Foundation; Royal Society; Canada Foundation for Innovation; Ontario Research Foundation; Natural Sciences and Engineering Research Council of Canada; Arthritis National Research Foundation; National Institutes of Health; Canada Research Chairs; Dr. Ralph and Marian Falk Medical Research Trust; European Regional Development Fund; International Business Machines Corporation; European Commission; U.S. Department of Defense; Xunta de Galicia","keywords":"Epigenomics; Genomics; Disease; Identification (biology); Computational biology; Omics; Bioinformatics; Biology; Medicine; Genome; Genetics; Pathology; DNA methylation; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003936733,0.0008844964,0.002505249,0.001977561,0.0003056836,0.002541241,0.00126561,0.002364001,0.003826101],"category_scores_gemma":[0.004834743,0.0003088953,0.0008807015,0.003056253,0.001446765,0.003745899,0.001345683,0.003559362,0.001421207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001089689,"about_ca_system_score_gemma":0.002760317,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001749734,"about_ca_topic_score_gemma":0.003605908,"domain_scores_codex":[0.9994397,0.0001608527,0.00008157094,0.0001037755,0.0001538007,0.00006022826],"domain_scores_gemma":[0.9961033,0.002576934,0.0002605932,0.00009031557,0.0007563588,0.0002123891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001798669,0.00005048166,0.0005536815,0.01844835,0.0002316916,0.0001238559,0.0001112976,0.0003827822,0.0008899868,0.009724695,0.03045487,0.9388484],"study_design_scores_gemma":[0.00004799779,0.000143997,0.002265392,0.01013784,0.0003696247,0.0006750131,0.0003007792,0.0002004912,0.0002906884,0.01028171,0.9752355,0.00005092633],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005336419,0.9978764,0.0001488539,0.001372534,0.0002898777,0.000001603194,0.00001533194,0.000005804194,0.0002362454],"genre_scores_gemma":[0.0004845875,0.9975903,0.0002836119,0.0009071371,0.0005013914,0.000003403174,0.00002303646,0.000001989635,0.0002045209],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003936733,"threshold_uncertainty_score":0.02081972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06343562286314604,"score_gpt":0.3398555398089951,"score_spread":0.2764199169458491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}