{"id":"W4392231952","doi":"10.3390/cells13050423","title":"Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets","year":2024,"lang":"en","type":"review","venue":"Cells","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Neuroinflammation; Inflammation; Dysbiosis; Medicine; Excitotoxicity; Gut–brain axis; Gut flora; Major depressive disorder; Antidepressant; Vitamin D and neurology; Neurochemical; Immunology; Bioinformatics; Glutamate receptor; Biology; Internal medicine; Amygdala; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001017962,0.0004069711,0.001132476,0.000290457,0.00004022074,0.00002806946,0.0007259565,0.0004354017,0.0006757482],"category_scores_gemma":[0.0001042995,0.0003241467,0.0003755186,0.0003668397,0.0001169936,0.00004658017,0.0004515282,0.0005610036,0.000977762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000469793,"about_ca_system_score_gemma":0.0001342257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000235829,"about_ca_topic_score_gemma":0.00001694078,"domain_scores_codex":[0.9974233,0.0004326856,0.0006267822,0.0008811108,0.000218153,0.0004179853],"domain_scores_gemma":[0.999089,0.0002866706,0.0002139861,0.0002666216,0.00001420268,0.0001295403],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005905159,0.0003372506,0.000001063287,0.0032923,0.00009199668,0.0004674318,0.0002601359,0.00005963855,0.4484656,0.001195762,0.002267445,0.5435023],"study_design_scores_gemma":[0.0007817007,0.0001400792,0.0000109944,0.001905758,0.0004869661,0.00001219247,0.00005936723,0.00006381758,0.09451612,0.01021166,0.891028,0.0007833614],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001665122,0.9949577,0.0001559227,0.000039084,0.001099873,0.001207969,0.0003559213,0.0000802475,0.0004380925],"genre_scores_gemma":[0.003907308,0.9950204,0.0001734758,0.000242089,0.0001202607,0.0002240489,0.00003404624,0.00006150665,0.0002168513],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8887605,"threshold_uncertainty_score":0.9999211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0183908899584705,"score_gpt":0.2918732024010224,"score_spread":0.2734823124425519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}