{"id":"W4392231952","doi":"10.3390/cells13050423","title":"Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets","year":2024,"lang":"en","type":"review","venue":"Cells","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; University of British Columbia","funders":"Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Neuroinflammation; Inflammation; Dysbiosis; Medicine; Excitotoxicity; Gut–brain axis; Gut flora; Major depressive disorder; Antidepressant; Vitamin D and neurology; Neurochemical; Immunology; Bioinformatics; Glutamate receptor; Biology; Internal medicine; Amygdala; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003633979,0.0006375518,0.001139552,0.00142329,0.0002157681,0.0007911088,0.0005794032,0.0007688499,0.001909574],"category_scores_gemma":[0.0003808806,0.0001960996,0.0004299448,0.001210933,0.0003876174,0.0007683768,0.00055322,0.001302683,0.0008184919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005351288,"about_ca_system_score_gemma":0.001004991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001265944,"about_ca_topic_score_gemma":0.002539363,"domain_scores_codex":[0.9998925,0.00002579181,0.00001906218,0.0000186579,0.00003248488,0.00001144949],"domain_scores_gemma":[0.9998521,0.00007134608,0.0000234092,0.000003685024,0.00003518993,0.00001441462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001155063,0.00007646924,0.0003967253,0.02393301,0.0001572665,0.0003088021,0.00009459745,0.0003660135,0.00200743,0.003823083,0.01985063,0.9488705],"study_design_scores_gemma":[0.00005291525,0.0002712563,0.004465565,0.01544261,0.000383688,0.00362975,0.0002355156,0.0003162814,0.0006426754,0.006166351,0.9683555,0.00003782591],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008582445,0.9992576,0.00004599901,0.0002231909,0.0000734908,0.000001870849,0.000006478137,0.000002271907,0.0003031601],"genre_scores_gemma":[0.0005302561,0.9990564,0.00006183807,0.00009278533,0.00008454358,0.000002669302,0.000008715331,3.779689e-7,0.0001625],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001909574,"threshold_uncertainty_score":0.006388187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0183908899584705,"score_gpt":0.2918732024010224,"score_spread":0.2734823124425519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}