{"id":"W4392234536","doi":"10.3390/ijms25052791","title":"Transforming Growth Factor Beta and Alveolar Rhabdomyosarcoma: A Challenge of Tumor Differentiation and Chemotherapy Response","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Sarcoma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; McGill University; Research Institute in Oncology and Hematology; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Alveolar rhabdomyosarcoma; Cancer research; Rhabdomyosarcoma; Bortezomib; Retinoic acid; Vincristine; Differentiation therapy; Chemotherapy; Biology; Medicine; Immunology; Internal medicine; Pathology; Cyclophosphamide; Acute promyelocytic leukemia; Sarcoma; Multiple myeloma; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007818353,0.0001332399,0.0004186717,0.0002113789,0.00008939416,0.0004153741,0.0001586441,0.0002743152,0.0005322491],"category_scores_gemma":[0.000962032,0.00005641777,0.0001629182,0.0002649399,0.0002201275,0.0003785037,0.0001951509,0.0006778335,0.0002200255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004287317,"about_ca_system_score_gemma":0.0004516304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003648616,"about_ca_topic_score_gemma":0.0007952311,"domain_scores_codex":[0.9996893,0.0001223766,0.00003802049,0.00003502291,0.00008981526,0.00002535693],"domain_scores_gemma":[0.9996098,0.0001633472,0.0001160552,0.00001567712,0.00005894688,0.0000362351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0008703903,0.0001648616,0.04823865,0.001637148,0.0002525536,0.001383156,0.0003181872,0.001153945,0.04703033,0.005051665,0.008063806,0.8858353],"study_design_scores_gemma":[0.0003528838,0.004108205,0.362893,0.002931976,0.001060735,0.04128294,0.002343847,0.007419734,0.05601244,0.01857906,0.5028715,0.0001436991],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1560216,0.8147168,0.003774434,0.01535455,0.0003963229,0.0000562632,0.0001779552,0.00008480442,0.009417296],"genre_scores_gemma":[0.7777799,0.2087523,0.004384332,0.00353124,0.0009129117,0.0000863583,0.0003396486,0.00003608705,0.00417723],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.0007818353,"threshold_uncertainty_score":0.004134774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01820550357583503,"score_gpt":0.3004192125850698,"score_spread":0.2822137090092347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}