{"id":"W4392236254","doi":"10.1007/s40265-024-02008-5","title":"Eplontersen: First Approval","year":2024,"lang":"en","type":"article","venue":"Drugs","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Transthyretin; Medicine; Amyloidosis; Polyneuropathy; Pharmacology; Antisense therapy; Internal medicine; Oligonucleotide; Biochemistry; Gene; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006689582,0.0001522218,0.0001087994,0.0000380067,0.0000551033,0.00005161894,0.0001335485,0.00009637277,0.00007559625],"category_scores_gemma":[0.00002381602,0.0001315671,0.0001445464,0.00007495074,0.00004938311,0.000003631944,0.00009216006,0.00006231659,0.0003571583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002558757,"about_ca_system_score_gemma":0.00003757734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000274182,"about_ca_topic_score_gemma":0.00002659962,"domain_scores_codex":[0.9991846,0.00001817861,0.000122243,0.0003627624,0.00009861908,0.0002135841],"domain_scores_gemma":[0.9995807,0.00002144207,0.00001957557,0.0002943788,0.00001660387,0.00006733469],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002127212,0.0008069207,0.05260999,0.0005582948,0.002086354,0.0003510791,0.003227138,0.00009689042,0.09941864,0.005781433,0.7520888,0.08276175],"study_design_scores_gemma":[0.000447136,0.0001376942,0.001761475,0.00004180884,0.00006232765,0.00002222202,0.0002621603,0.00009680054,0.08294724,0.00007636596,0.9138689,0.000275838],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650798,0.00839891,0.0004221505,0.005590545,0.001115165,0.0003477628,0.00007031533,0.0001902956,0.01878506],"genre_scores_gemma":[0.9929414,0.0004089581,0.0003647834,0.0005508909,0.0003229202,0.00007936887,0.000104331,0.00003716715,0.005190203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1617801,"threshold_uncertainty_score":0.5365149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007552506774510605,"score_gpt":0.2517355677165025,"score_spread":0.2441830609419919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}