{"id":"W4392236254","doi":"10.1007/s40265-024-02008-5","title":"Eplontersen: First Approval","year":2024,"lang":"en","type":"article","venue":"Drugs","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Transthyretin; Medicine; Amyloidosis; Polyneuropathy; Pharmacology; Antisense therapy; Internal medicine; Oligonucleotide; Biochemistry; Gene; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009092856,0.0008478998,0.0008212165,0.0006119407,0.0003695436,0.001901357,0.001043894,0.002879924,0.09487906],"category_scores_gemma":[0.001718246,0.0002358501,0.0009231468,0.000474443,0.0004001802,0.001071768,0.0005354148,0.002991863,0.03616142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008458336,"about_ca_system_score_gemma":0.001684502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000601774,"about_ca_topic_score_gemma":0.00151662,"domain_scores_codex":[0.9995043,0.0001016937,0.00003248707,0.00007057443,0.000204524,0.00008629471],"domain_scores_gemma":[0.9993221,0.00008998216,0.0001160127,0.00004935871,0.0001988077,0.0002237225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003185013,0.000400812,0.0004903997,0.001995258,0.0001342848,0.0007463458,0.00005382508,0.0002771656,0.005929801,0.005354054,0.5475819,0.4338511],"study_design_scores_gemma":[0.002779043,0.001161354,0.001168671,0.0005551844,0.00005273349,0.001169665,0.00001113356,0.000157902,0.001232982,0.0008147728,0.9908828,0.00001377087],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.0292271,0.1975247,0.004885575,0.03802283,0.01423524,0.002505914,0.03032133,0.0053968,0.6778805],"genre_scores_gemma":[0.1949506,0.1378819,0.007518541,0.04453807,0.008514144,0.002208467,0.04784226,0.0009660822,0.55558],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.09487906,"threshold_uncertainty_score":0.3174021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007552506774510605,"score_gpt":0.2517355677165025,"score_spread":0.2441830609419919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}