{"id":"W4392236627","doi":"10.1101/2024.02.27.582393","title":"Profound synthetic lethality between SMARCAL1 and FANCM","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; University of New Brunswick; Telesta Therapeutics (Canada); Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Biology; Genome instability; Genome; DNA replication; Genetics; DNA damage; DNA repair; Translocase; DNA; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003252485,0.0007079904,0.0003265273,0.0006593465,0.0002419348,0.0003067819,0.0004188015,0.0005864422,0.002891548],"category_scores_gemma":[0.0002199903,0.0001693211,0.0002948475,0.000267978,0.0003906325,0.0001256213,0.0006593305,0.0006935003,0.0006869206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003362731,"about_ca_system_score_gemma":0.0001912833,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007996137,"about_ca_topic_score_gemma":0.0007279231,"domain_scores_codex":[0.9994936,0.0001011042,0.00004466436,0.0000918103,0.0001984152,0.00007037741],"domain_scores_gemma":[0.9996878,0.00009445159,0.00009074731,0.0000324289,0.00001564668,0.00007901349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007792736,0.00001751545,0.000177617,0.00001847771,0.000009589202,0.0001712896,0.000009403461,0.0001533292,0.9984217,0.0001575511,0.00007285454,0.0007127565],"study_design_scores_gemma":[0.00001173223,0.0001274282,0.002160866,0.000005108148,0.00001050003,0.0006790694,0.00001981209,0.001406463,0.9930469,0.00004909922,0.002475182,0.000007723622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831486,0.0007221825,0.01046272,0.000207077,0.00005893984,0.00006669733,0.002114213,0.0005844418,0.002635131],"genre_scores_gemma":[0.9924896,0.0001497621,0.002676029,0.00005572247,0.00000676305,0.00003383232,0.001042844,0.0001069535,0.003438567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002891548,"threshold_uncertainty_score":0.009673178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01339378935177164,"score_gpt":0.2355807903659596,"score_spread":0.2221870010141879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}