{"id":"W4392238374","doi":"10.1021/acsabm.3c01253","title":"Diatomite-Based, Flexible SERS Immunosensor Platform for Rapid, Specific, and Sensitive Detection of Circulating Cancer-Specific Protein Biomarkers in Serum Using Raman Probes","year":2024,"lang":"en","type":"article","venue":"ACS Applied Bio Materials","topic":"Gold and Silver Nanoparticles Synthesis and Applications","field":"Materials Science","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada; Türkiye Bilimler Akademisi; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu","keywords":"Detection limit; Immunoassay; Antigen; Reproducibility; Cancer; Antibody; Raman spectroscopy; Chromatography; Chemistry; Materials science; Molecular biology; Nanotechnology; Biomedical engineering; Medicine; Immunology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003016249,0.0007059587,0.0002450714,0.0003773759,0.0001686822,0.0003428668,0.0006658143,0.000729729,0.000521566],"category_scores_gemma":[0.0003181281,0.00038532,0.0002697262,0.0002767612,0.0002741772,0.0003326905,0.000489414,0.0005020646,0.000320557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002924175,"about_ca_system_score_gemma":0.0002504216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004111591,"about_ca_topic_score_gemma":0.0007371082,"domain_scores_codex":[0.9997014,0.00004103544,0.00001860214,0.00009255164,0.0001134282,0.00003288952],"domain_scores_gemma":[0.9998803,0.00002579421,0.00003243437,0.00001345543,0.0000305652,0.00001747625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004805898,0.00002341616,0.0001481009,0.00006077496,0.000007254935,0.00009041782,0.00001378378,0.000300577,0.9948486,0.0001985713,0.0001463701,0.004114217],"study_design_scores_gemma":[0.0000142835,0.0001594488,0.0006974997,0.000003422351,0.00001121114,0.0002027376,0.00001700119,0.008228386,0.9887978,0.00008811086,0.001765561,0.00001449298],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7684337,0.004111452,0.2169725,0.0005640623,0.0002215459,0.0001798452,0.0004537495,0.001295179,0.007767965],"genre_scores_gemma":[0.9213485,0.001263687,0.07250022,0.000186315,0.00002458653,0.000118135,0.0003149981,0.00002968491,0.00421391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000729729,"threshold_uncertainty_score":0.002121687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03081075304870449,"score_gpt":0.25526039007653,"score_spread":0.2244496370278255,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}