{"id":"W4392243978","doi":"10.1101/2024.02.26.582098","title":"Mitochondrial antigen-specific CD8⁺ T cells drive dopamine neuron neurodegeneration","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; Montreal Neurological Institute and Hospital; Montreal Clinical Research Institute; Hôpital Maisonneuve-Rosemont; Université de Montréal","funders":"Canadian Institutes of Health Research; Krembil Foundation; Michael J. Fox Foundation for Parkinson's Research","keywords":"Adoptive cell transfer; Parkinsonism; Cytotoxic T cell; Mitochondrion; Biology; PINK1; Neuroscience; Neuroinflammation; Parkinson's disease; Dopamine; Immunology; Cell biology; T cell; Autoimmunity; Immune system; Medicine; Parkin; Pathology; Disease; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001344173,0.0002688212,0.0001461177,0.000254701,0.0001715177,0.0002634568,0.0001530334,0.0002639138,0.002787068],"category_scores_gemma":[0.0001056236,0.00009832688,0.0001414813,0.0001008471,0.0002283999,0.00013201,0.0002759526,0.0007658621,0.001128163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002303648,"about_ca_system_score_gemma":0.0001100385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002508919,"about_ca_topic_score_gemma":0.0003975946,"domain_scores_codex":[0.9999045,0.00001042172,0.000007124773,0.00002461919,0.00003275533,0.00002049974],"domain_scores_gemma":[0.999907,0.00001676241,0.00001845791,0.00001265689,0.00001483684,0.00003035743],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001528656,0.0000598764,0.000416043,0.00004066739,0.000005773332,0.0001850675,0.00003928438,0.0001258197,0.9947671,0.0008866624,0.0004467081,0.002874148],"study_design_scores_gemma":[0.00007403978,0.0002283415,0.003430435,0.00001678224,0.00001682494,0.0009462566,0.0000729595,0.002247889,0.9827669,0.000904844,0.009290208,0.000004584431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862393,0.0007949561,0.003926776,0.000443566,0.0001268635,0.00002423881,0.0002999096,0.0001869541,0.007957427],"genre_scores_gemma":[0.9771606,0.0004838829,0.004556197,0.0001595958,0.00005990925,0.00003927363,0.0004679653,0.00006504922,0.01700746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002787068,"threshold_uncertainty_score":0.009323597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02237098675046616,"score_gpt":0.2235991154636254,"score_spread":0.2012281287131593,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}