{"id":"W4392244035","doi":"10.1101/2024.02.25.581948","title":"Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of General Medical Sciences; Khalifa Bin Zayed Al Nahyan Foundation; Vanderbilt Digestive Diseases Research Center, Vanderbilt University Medical Center; University of Texas MD Anderson Cancer Center; National Institute of Diabetes and Digestive and Kidney Diseases; Sky Foundation; American Gastroenterological Association; Vanderbilt University Medical Center; National Cancer Institute; National Institutes of Health; Vanderbilt-Ingram Cancer Center; Vanderbilt University; U.S. Department of Defense","keywords":"GNAS complex locus; Pylorus; Pancreas; Medicine; Internal medicine; Gastroenterology; Stomach; General surgery; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701381,0.0003444653,0.0001934663,0.0002771137,0.000156943,0.0003260896,0.000245399,0.0003715559,0.00169713],"category_scores_gemma":[0.0001376907,0.0001674358,0.0003596327,0.0002054928,0.0003951161,0.00008464186,0.0002788667,0.0005445256,0.0006206583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004515391,"about_ca_system_score_gemma":0.0002876061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009411864,"about_ca_topic_score_gemma":0.001636567,"domain_scores_codex":[0.9998171,0.00002453018,0.00002217079,0.00004473326,0.00006277708,0.00002865679],"domain_scores_gemma":[0.9998146,0.00002287096,0.00006640234,0.00002416193,0.00001250505,0.00005953062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009849758,0.00002445153,0.000324061,0.00002142539,0.000005537924,0.00009080488,0.00001251752,0.00010476,0.9984302,0.00008827725,0.00006424971,0.0007350355],"study_design_scores_gemma":[0.00005611168,0.000343634,0.01374014,0.0000163558,0.00003554027,0.001060046,0.0000924284,0.004716708,0.9745326,0.0001457925,0.005246797,0.00001387287],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938393,0.0002369955,0.003147234,0.0001351593,0.00003827603,0.00004251187,0.001091154,0.0003068105,0.00116244],"genre_scores_gemma":[0.9926247,0.0002016594,0.003187073,0.00008110346,0.000005310722,0.00004803531,0.0009579354,0.00009310715,0.002801164],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00169713,"threshold_uncertainty_score":0.005677462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126863644850963,"score_gpt":0.2520767763370812,"score_spread":0.2393904118519849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}