{"id":"W4392245674","doi":"10.1016/j.atherosclerosis.2024.117501","title":"Drug target Mendelian randomization supports apolipoprotein C3-lowering for lipoprotein-lipid levels reductions and cardiovascular diseases prevention","year":2024,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"Fonds de Recherche du Québec - Santé","keywords":"Mendelian randomization; Medicine; Internal medicine; Odds ratio; Apolipoprotein B; Single-nucleotide polymorphism; Endocrinology; Genome-wide association study; Cholesterol; Bioinformatics; Genetics; Biology; Genotype; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004731576,0.0002558038,0.0005393355,0.0001830741,0.0002180045,0.0001215241,0.00006342566,0.00009881477,0.0001655561],"category_scores_gemma":[0.0001521893,0.0002265291,0.0005473417,0.0002977212,0.00008382264,0.0003450907,0.00004077166,0.0001112683,0.00001329499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004176193,"about_ca_system_score_gemma":0.0001201348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003143656,"about_ca_topic_score_gemma":0.00001190376,"domain_scores_codex":[0.9983332,0.00006324666,0.0003673395,0.0005770136,0.0003204016,0.0003388713],"domain_scores_gemma":[0.9991892,0.00003969925,0.0000532933,0.0004167095,0.00008851337,0.0002126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002173727,0.001640922,0.005102982,0.007247144,0.007338771,0.00001402074,0.008410498,0.001420921,0.1770582,0.003222611,0.02825313,0.7581171],"study_design_scores_gemma":[0.06785149,0.001398412,0.07952295,0.006003981,0.01864929,0.0001756322,0.005467798,0.00887402,0.2557591,0.01826614,0.5339743,0.004056877],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8569772,0.03059071,0.09753788,0.002475453,0.003144914,0.007306254,0.0004522137,0.0009242735,0.0005910972],"genre_scores_gemma":[0.9906874,0.001125354,0.003596105,0.00009196512,0.001061635,0.0009811597,0.0001622787,0.00009384895,0.002200274],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7540601,"threshold_uncertainty_score":0.9237588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01933512321196666,"score_gpt":0.2644946239375054,"score_spread":0.2451595007255387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}