{"id":"W4392246465","doi":"10.1016/j.esmoop.2024.102273","title":"44O Updated results from a phase I study evaluating the KRAS G12C inhibitor MK-1084 in solid tumors and in combination with pembrolizumab in NSCLC","year":2024,"lang":"en","type":"article","venue":"ESMO Open","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; University of Toronto; McMaster University","funders":"","keywords":"KRAS; Pembrolizumab; Medicine; Cancer research; Internal medicine; Oncology; Cancer; Colorectal cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006547456,0.000148854,0.0003485678,0.0001391071,0.00006606853,0.0001083252,0.00009350109,0.00002941227,0.00004448196],"category_scores_gemma":[0.0001261724,0.00008883786,0.00001423387,0.0004725626,0.00004300087,0.000146746,0.0001640539,0.0002235213,0.000005403465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002403786,"about_ca_system_score_gemma":0.0001705203,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.0168485,"about_ca_topic_score_gemma":0.04038601,"domain_scores_codex":[0.9987246,0.0001512782,0.0003454151,0.0003801098,0.0002294679,0.0001690657],"domain_scores_gemma":[0.9995454,0.0001654595,0.00005166901,0.0001673254,0.00003761974,0.00003253984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0907473,0.01067321,0.53978,0.0001110558,0.0008797562,0.005138736,0.1890248,0.0001577422,0.0006622123,0.0001212732,0.001952466,0.1607514],"study_design_scores_gemma":[0.0584988,0.006830841,0.9166414,0.001118005,0.0001148612,0.00001315118,0.01011473,0.005855909,0.0002690964,0.0002120654,0.0001586726,0.0001724659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929882,0.0003375261,4.351174e-7,0.001845164,0.00006897363,0.002392619,0.00002930454,0.00001746072,0.002320274],"genre_scores_gemma":[0.9991605,0.00002028934,0.0000295315,0.00007855819,0.00003152129,0.0003125512,0.00009012832,0.00001549601,0.0002614377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3768614,"threshold_uncertainty_score":0.9896984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04750845522952496,"score_gpt":0.4015019755190461,"score_spread":0.3539935202895211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}