{"id":"W4392247444","doi":"10.1016/j.omton.2024.200783","title":"Conditionally replicative adenovirus as a therapy for malignant peripheral nerve sheath tumors","year":2024,"lang":"en","type":"article","venue":"Molecular Therapy Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Institute of Neurological Disorders and Stroke; National Cancer Institute; Children's Cancer Research Fund; National Institutes of Health; American Cancer Society","keywords":"Oncolytic virus; Cancer research; Neurofibromatosis; Oncolytic adenovirus; CD8; Malignant peripheral nerve sheath tumor; In vivo; Immunotherapy; Biology; Medicine; Immunology; Pathology; Immune system; Tumor cells","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000210619,0.0003736522,0.0001670706,0.0001987352,0.00007662402,0.0003080519,0.0002272764,0.0002591412,0.0006539595],"category_scores_gemma":[0.0001268872,0.00007551051,0.0001438552,0.000104275,0.000290344,0.0002507372,0.000159663,0.0003773761,0.0001843757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003285977,"about_ca_system_score_gemma":0.0002992678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00053028,"about_ca_topic_score_gemma":0.0005563494,"domain_scores_codex":[0.999882,0.00002572249,0.000008162287,0.00002474853,0.00003865501,0.00002079215],"domain_scores_gemma":[0.9999462,0.00001208336,0.00001564576,0.00001095161,0.000005974707,0.000009152332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007815799,0.00004169508,0.0001168523,0.00005440797,0.000004098163,0.00004359484,0.0000149803,0.0002467727,0.9955291,0.0005815093,0.00004748078,0.003241178],"study_design_scores_gemma":[0.00001987629,0.0008729316,0.0006562493,0.000009297689,0.00002039003,0.0003680758,0.00001388874,0.001242792,0.9904106,0.00008273121,0.006297506,0.000005714749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685006,0.007513387,0.02008842,0.0001585008,0.0001096827,0.0001291116,0.000310175,0.0002876894,0.002902462],"genre_scores_gemma":[0.9844525,0.003391316,0.008823001,0.00002994717,0.0000132092,0.00005476398,0.0002867638,0.00002378858,0.002924713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006539595,"threshold_uncertainty_score":0.002384186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0252161962129652,"score_gpt":0.3544983500566761,"score_spread":0.3292821538437109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}