{"id":"W4392283093","doi":"10.1371/journal.pbio.3002544","title":"Ebola virus VP35 interacts non-covalently with ubiquitin chains to promote viral replication","year":2024,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Viral Infections and Outbreaks Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Alliance de recherche numérique du Canada; Natural Sciences and Engineering Research Council of Canada; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Ebola virus; Polymerase; Ebolavirus; Viral replication; Biology; Ubiquitin; Virology; Virus; Cell biology; Genetics; Biochemistry; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001914808,0.0001262083,0.0002089176,0.0002524228,0.00006076884,0.00003463393,0.0000807185,0.0001031394,0.0002010454],"category_scores_gemma":[0.0001017021,0.00008573288,0.00005269309,0.0003108162,0.00007921331,0.0000605215,0.00007589677,0.0002972606,0.0007460539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009789484,"about_ca_system_score_gemma":0.00009988427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001551717,"about_ca_topic_score_gemma":0.00008060476,"domain_scores_codex":[0.9988981,0.00004167495,0.0001823181,0.0004693345,0.0001030334,0.0003054955],"domain_scores_gemma":[0.9993162,0.00003410975,0.0000226741,0.0003727708,0.0001097093,0.0001445709],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002606079,0.0001862514,0.0006011862,0.0001221531,0.000122877,0.00006170281,0.0003455764,0.00000109873,0.9637518,0.0009943828,0.001363484,0.03218888],"study_design_scores_gemma":[0.0007846518,0.005851458,0.006827181,0.0005793734,0.0001037602,0.0003377583,0.00005603963,0.004484147,0.8530428,0.0001878399,0.1274728,0.0002721841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850976,0.0001138627,0.001661386,0.005483795,0.0001370755,0.0007657368,0.00003045671,0.0001667979,0.006543267],"genre_scores_gemma":[0.9939461,0.000042107,0.0005136519,0.0007863071,0.0003521755,0.0001797538,0.000085063,0.00002707016,0.004067716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1261093,"threshold_uncertainty_score":0.9589263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03225796241624895,"score_gpt":0.3593330385408061,"score_spread":0.3270750761245572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}