{"id":"W4392287332","doi":"10.3324/haematol.2023.283713","title":"Adjusting for subsequent therapies in the TOURMALINE-MM1 study shows clinically meaningful improvement in overall survival with addition of ixazomib to lenalidomide and dexamethasone","year":2024,"lang":"en","type":"article","venue":"Haematologica","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital; University of Calgary","funders":"Loxo Oncology; Adaptive Biotechnologies; Regeneron Pharmaceuticals; Genentech; Celgene; BeiGene; Sanofi; Pfizer; Amgen","keywords":"Lenalidomide; Medicine; Internal medicine; Hazard ratio; Ixazomib; Population; Confidence interval; Dexamethasone; Surgery; Oncology; Carfilzomib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008617246,0.0006547384,0.00114645,0.0002767436,0.0001449845,0.0007405377,0.0006202629,0.0005609158,0.001487119],"category_scores_gemma":[0.01162814,0.0002484375,0.006162563,0.0003617892,0.0002927755,0.0004409462,0.0006148865,0.001660784,0.0001240832],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006360881,"about_ca_system_score_gemma":0.001160365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002624129,"about_ca_topic_score_gemma":0.004086443,"domain_scores_codex":[0.9936326,0.004755707,0.0002038673,0.0007461417,0.0004056134,0.0002561899],"domain_scores_gemma":[0.9943204,0.0034823,0.001182916,0.0007024787,0.00009599508,0.0002158277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4069819,0.001541018,0.2343394,0.002949172,0.05066736,0.0002935655,0.0005835851,0.02204424,0.006036714,0.002567677,0.003725801,0.2682695],"study_design_scores_gemma":[0.04469047,0.1461057,0.6524412,0.0007279246,0.05149832,0.0006469821,0.000260503,0.07429349,0.01045637,0.006155354,0.01256899,0.0001547292],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850056,0.006760253,0.005280269,0.0005607627,0.0001117783,0.0002004268,0.001122817,0.0001022573,0.0008557495],"genre_scores_gemma":[0.9960296,0.000644878,0.001746427,0.0001714098,0.00004944227,0.0001041421,0.0006201825,0.00001831006,0.0006157017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008617246,"threshold_uncertainty_score":0.04557294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08382698583699201,"score_gpt":0.375925104901556,"score_spread":0.292098119064564,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}