{"id":"W4392288363","doi":"10.1002/adma.202313226","title":"Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy","year":2024,"lang":"en","type":"article","venue":"Advanced Materials","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Pennsylvania; National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Perelman School of Medicine, University of Pennsylvania; National Institutes of Health; Canadian Aeronautics and Space Institute; National Center for Advancing Translational Sciences; Division of Chemical, Bioengineering, Environmental, and Transport Systems; National Cancer Institute; National Science Foundation; Emerson Collective","keywords":"Materials science; Cancer immunotherapy; Immunotherapy; Cancer; Cell; Nanoparticle; Nanotechnology; Cancer research; Medicine; Biology; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477867,0.0002936838,0.00013772,0.000172181,0.0001039105,0.000288974,0.0001776448,0.0003917104,0.0008364652],"category_scores_gemma":[0.0001540105,0.0001141521,0.0001527131,0.00009596212,0.0001350914,0.0002617812,0.0002484072,0.0003219653,0.0005577259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002800844,"about_ca_system_score_gemma":0.0001710314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002513344,"about_ca_topic_score_gemma":0.0003577012,"domain_scores_codex":[0.9998919,0.00002172935,0.000006079761,0.00002337598,0.00003816,0.00001880203],"domain_scores_gemma":[0.9999568,0.00001040585,0.00001172609,0.000004041818,0.00001031516,0.000006685188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004270003,0.00002852261,0.0000483766,0.00005101826,0.00000340398,0.00005307089,0.00001758298,0.0004250569,0.992459,0.0005078305,0.0001790043,0.006184265],"study_design_scores_gemma":[0.00001239202,0.0001615048,0.0001262408,0.000003768713,0.000008831297,0.00008945326,0.0000084197,0.003655908,0.9911836,0.00008811514,0.004657201,0.000004475957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8596656,0.003986801,0.1233907,0.00051298,0.0001891482,0.0002968702,0.000235506,0.0009258913,0.01079634],"genre_scores_gemma":[0.9669185,0.001026279,0.02729624,0.000123273,0.00002265818,0.0001168517,0.0001248403,0.00004529746,0.00432597],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008364652,"threshold_uncertainty_score":0.002798259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02429534248655237,"score_gpt":0.3365589295503751,"score_spread":0.3122635870638227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}