{"id":"W4392288363","doi":"10.1002/adma.202313226","title":"Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy","year":2024,"lang":"en","type":"article","venue":"Advanced Materials","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Pennsylvania; National Institute of Dental and Craniofacial Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Perelman School of Medicine, University of Pennsylvania; National Institutes of Health; Canadian Aeronautics and Space Institute; National Center for Advancing Translational Sciences; Division of Chemical, Bioengineering, Environmental, and Transport Systems; National Cancer Institute; National Science Foundation; Emerson Collective","keywords":"Materials science; Cancer immunotherapy; Immunotherapy; Cancer; Cell; Nanoparticle; Nanotechnology; Cancer research; Medicine; Biology; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006138005,0.0002744494,0.0005229155,0.00015149,0.0001001053,0.0001690755,0.0001857889,0.000106026,0.003912481],"category_scores_gemma":[0.00004685466,0.0002363224,0.0001700531,0.0002399351,0.00008354103,0.0001898178,0.00006093553,0.0001195243,0.00008525436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001532746,"about_ca_system_score_gemma":0.0002028765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000918356,"about_ca_topic_score_gemma":0.000004663531,"domain_scores_codex":[0.9978012,0.00007847195,0.0004817937,0.0005379425,0.0004054544,0.0006951237],"domain_scores_gemma":[0.9988872,0.0002285487,0.0000878104,0.0004791857,0.0001793374,0.0001378586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007296796,0.00009178772,0.00007009963,0.0009194862,0.00009836788,0.00002868654,0.0004699741,0.00002558361,0.9739197,0.00002686399,0.0009426305,0.02267715],"study_design_scores_gemma":[0.001554774,0.0002288967,0.0001322283,0.0001602925,0.00003972156,0.00000794695,0.00006961993,0.00004308889,0.7696784,0.0001368524,0.227756,0.0001921365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795569,0.01498402,0.00007163381,0.0004385072,0.001672291,0.001750301,0.0001114939,0.000349672,0.001065242],"genre_scores_gemma":[0.9744691,0.009249627,0.002626844,0.0002209817,0.001015379,0.0006308433,0.00003839193,0.000238586,0.01151024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2268134,"threshold_uncertainty_score":0.9969981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02429534248655237,"score_gpt":0.3365589295503751,"score_spread":0.3122635870638227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}