{"id":"W4392296240","doi":"10.3390/molecules29051084","title":"Synthesis and Photolysis Properties of a New Chloroquine Photoaffinity Probe","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Chemical Reactions and Mechanisms","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Wellcome Trust","keywords":"Chemistry; Amine gas treating; Azide; Nitrene; Quinoline; Pyridine; Photochemistry; Photoaffinity labeling; Aminoquinolines; Photodissociation; Derivative (finance); Convergent synthesis; Combinatorial chemistry; Medicinal chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003294786,0.00009843673,0.0001421969,0.00003380058,0.00002291048,0.00003412756,0.00006502777,0.00006144688,0.0008585213],"category_scores_gemma":[0.0001181143,0.00007656762,0.00006586729,0.00009052854,0.0000395914,0.00003971235,0.00004707215,0.00008051234,0.00001535927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001805644,"about_ca_system_score_gemma":0.00004855721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002042654,"about_ca_topic_score_gemma":0.000006896355,"domain_scores_codex":[0.9994661,0.000002996195,0.0001301078,0.0001858892,0.0001050033,0.0001099382],"domain_scores_gemma":[0.9997099,0.00003504907,0.00002262722,0.0001452823,0.0000189303,0.00006819647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001654713,0.00003267581,0.000002628136,0.0003717012,0.00004688717,0.000006363258,0.000116738,3.920859e-7,0.9763516,0.0001954663,0.0001855916,0.02267339],"study_design_scores_gemma":[0.00005875665,0.000007189527,0.00000215732,0.0002996523,0.00006606778,0.00001313734,0.00007673978,0.00046253,0.9896434,0.0003258593,0.008955442,0.0000890762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900392,0.002856301,0.0002824662,0.0001512726,0.00002068522,0.00004729533,0.00001576052,0.0001057325,0.006481325],"genre_scores_gemma":[0.9953884,0.0001511624,0.0006715395,0.00001249141,0.0000368576,0.00003438002,0.000002409547,0.00001714926,0.003685533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02258431,"threshold_uncertainty_score":0.9400207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01890339691575358,"score_gpt":0.2219233868737563,"score_spread":0.2030199899580027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}