{"id":"W4392296240","doi":"10.3390/molecules29051084","title":"Synthesis and Photolysis Properties of a New Chloroquine Photoaffinity Probe","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Chemical Reactions and Mechanisms","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Wellcome Trust","keywords":"Chemistry; Amine gas treating; Azide; Nitrene; Quinoline; Pyridine; Photochemistry; Photoaffinity labeling; Aminoquinolines; Photodissociation; Derivative (finance); Convergent synthesis; Combinatorial chemistry; Medicinal chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001443087,0.0002723207,0.0002613707,0.0001234567,0.0001901173,0.0001962492,0.0002708601,0.0003823233,0.001399345],"category_scores_gemma":[0.0001529091,0.0001401693,0.0001752549,0.00008405917,0.000233867,0.0001846724,0.0001890706,0.0004770326,0.0005407639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004091168,"about_ca_system_score_gemma":0.0001915427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007778325,"about_ca_topic_score_gemma":0.001544217,"domain_scores_codex":[0.9998838,0.00001646002,0.000004589518,0.00003304607,0.00003095109,0.00003107463],"domain_scores_gemma":[0.999868,0.00003263522,0.00002576537,0.00002041251,0.00002394516,0.00002923734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001471216,0.000002436137,0.00002200666,0.00001513173,0.00000109027,0.00001548671,0.000007326155,0.00002291246,0.9993706,0.0000438589,0.00001153703,0.0004729862],"study_design_scores_gemma":[0.000003199124,0.00005299424,0.0004190911,0.000001097846,0.000003604894,0.00008597165,0.000004001648,0.0001425729,0.9981499,0.000009886979,0.001124547,0.000003161925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9639668,0.002786258,0.02655999,0.0002109158,0.00003629286,0.0001113877,0.0003705971,0.0001716127,0.005786065],"genre_scores_gemma":[0.9787862,0.0009995145,0.01415803,0.000111672,0.00001662446,0.000065727,0.0004883398,0.00002957453,0.005344268],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001399345,"threshold_uncertainty_score":0.00468123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01890339691575358,"score_gpt":0.2219233868737563,"score_spread":0.2030199899580027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}