{"id":"W4392302540","doi":"10.1016/j.xgen.2024.100511","title":"Genomic evolution shapes prostate cancer disease type","year":2024,"lang":"en","type":"article","venue":"Cell Genomics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Cancer Research UK Cambridge Institute, University of Cambridge; NIHR Cambridge Biomedical Research Centre; Canadian Institutes of Health Research; Syöpäjärjestöt; National Institutes of Health; H2020 Marie Skłodowska-Curie Actions; Masonic Charitable Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Prostate Cancer Canada; Prostate Cancer UK; National Institute for Health and Care Research; Sigrid Juséliuksen Säätiö; National Cancer Research Institute; Royal Marsden NHS Foundation Trust; National Health and Medical Research Council; University of St Andrews; Horizon 2020 Framework Programme; Academy of Finland; University of Cambridge; Wellcome Trust; Cancer Research UK; Hutchison Whampoa Limited; Ontario Institute for Cancer Research; Francis Crick Institute; Medical Research Council; Cancer Prevention and Research Institute of Texas","keywords":"Prostate cancer; Cancer; Biology; Disease; Computational biology; Prostate; Somatic evolution in cancer; Androgen receptor; Chromoplexy; Evolutionary biology; Cancer research; Genetics; Medicine; Internal medicine; PCA3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003654769,0.0001300715,0.0002965641,0.0009985066,0.0002560521,0.000948813,0.0002552073,0.0004262985,0.001870165],"category_scores_gemma":[0.001243369,0.0001219579,0.0002640303,0.0007603184,0.0003631834,0.0002675351,0.0003380998,0.0004599673,0.0003008342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003351481,"about_ca_system_score_gemma":0.0002730195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320021,"about_ca_topic_score_gemma":0.002035049,"domain_scores_codex":[0.9997126,0.00006886471,0.000009960518,0.000112071,0.00005056835,0.00004587549],"domain_scores_gemma":[0.9993829,0.0001741677,0.0002048052,0.00006440977,0.00008974381,0.00008401692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007477432,0.00006569819,0.8141245,0.0000817741,0.000259768,0.0004473507,0.00055027,0.006207984,0.12001,0.005925417,0.0006443193,0.05093518],"study_design_scores_gemma":[0.00001193984,0.0001658081,0.9670534,0.00001598836,0.0001005269,0.001639837,0.0004142112,0.01320494,0.007764632,0.005005307,0.004589028,0.00003444631],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99321,0.0007540865,0.003433928,0.000124725,0.000009844468,0.00001010195,0.0003845371,0.00003962749,0.002033191],"genre_scores_gemma":[0.998323,0.0002170403,0.0007949735,0.00004707601,0.000007661019,0.000003949324,0.0002354398,0.00001897915,0.0003519571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001870165,"threshold_uncertainty_score":0.006256282,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068688260702288,"score_gpt":0.3005653964888934,"score_spread":0.2798785138818705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}