{"id":"W4392302540","doi":"10.1016/j.xgen.2024.100511","title":"Genomic evolution shapes prostate cancer disease type","year":2024,"lang":"en","type":"article","venue":"Cell Genomics","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Cancer Research UK Cambridge Institute, University of Cambridge; NIHR Cambridge Biomedical Research Centre; Canadian Institutes of Health Research; Syöpäjärjestöt; National Institutes of Health; H2020 Marie Skłodowska-Curie Actions; Masonic Charitable Foundation; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Prostate Cancer Canada; Prostate Cancer UK; National Institute for Health and Care Research; Sigrid Juséliuksen Säätiö; National Cancer Research Institute; Royal Marsden NHS Foundation Trust; National Health and Medical Research Council; University of St Andrews; Horizon 2020 Framework Programme; Academy of Finland; University of Cambridge; Wellcome Trust; Cancer Research UK; Hutchison Whampoa Limited; Ontario Institute for Cancer Research; Francis Crick Institute; Medical Research Council; Cancer Prevention and Research Institute of Texas","keywords":"Prostate cancer; Cancer; Biology; Disease; Computational biology; Prostate; Somatic evolution in cancer; Androgen receptor; Chromoplexy; Evolutionary biology; Cancer research; Genetics; Medicine; Internal medicine; PCA3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007256871,0.0001273916,0.0001294072,0.0001020487,0.00006856691,0.00005423131,0.00006332383,0.00004418702,0.0003391127],"category_scores_gemma":[0.000006094072,0.0001006446,0.00007271409,0.0001903069,0.000060484,0.00005399592,0.00004814462,0.0001513594,0.0005735757],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000822551,"about_ca_system_score_gemma":0.001076368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005312927,"about_ca_topic_score_gemma":0.000005935008,"domain_scores_codex":[0.9991452,0.00001300282,0.0001286657,0.000296892,0.0001284789,0.0002878133],"domain_scores_gemma":[0.9995157,0.00001696517,0.00001677767,0.0001531852,0.00006304516,0.0002343223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004870377,0.0005179718,0.1066146,0.004134292,0.0006447216,0.001602173,0.00339123,0.001229314,0.7771572,0.001077707,0.03907312,0.05968724],"study_design_scores_gemma":[0.003957886,0.0007237867,0.1640138,0.0006005952,0.001065946,0.00004075303,0.0004304206,0.03364791,0.01709315,0.002485008,0.775088,0.0008526905],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8961461,0.09853942,0.00003924021,0.001245116,0.0005430196,0.0005888807,0.00007892843,0.0001232447,0.002696084],"genre_scores_gemma":[0.9554884,0.009864327,0.0001336413,0.0001186955,0.0004270734,0.00006101403,0.00009297546,0.00004839794,0.03376545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7600641,"threshold_uncertainty_score":0.7372347,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02068688260702288,"score_gpt":0.3005653964888934,"score_spread":0.2798785138818705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}