{"id":"W4392342344","doi":"10.1101/2024.03.01.582838","title":"O-GlcNAcylation of FOXK1 orchestrates the E2F pathway and promotes oncogenesis","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Montreal Clinical Research Institute; Université de Montréal; Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health","keywords":"Carcinogenesis; Cell biology; E2F; Cancer research; Chemistry; Biology; Genetics; Transcription factor; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007485272,0.000293916,0.0001963889,0.0002520622,0.0001873837,0.0002830294,0.0001134615,0.0001673161,0.001312601],"category_scores_gemma":[0.00006405542,0.0001027527,0.0002418811,0.0001682188,0.0001886087,0.0001720383,0.0002327625,0.0002638982,0.0004392304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005054033,"about_ca_system_score_gemma":0.0001874984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008875242,"about_ca_topic_score_gemma":0.001310241,"domain_scores_codex":[0.9999285,0.000004915144,0.000002866437,0.0000175253,0.00001311263,0.00003311149],"domain_scores_gemma":[0.9999542,0.000004218668,0.00001432839,0.000004384555,0.000006376886,0.00001655369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001648253,0.0000240451,0.001172081,0.00003843165,0.000005454688,0.0000751378,0.00001660759,0.00006014918,0.9969307,0.0001591053,0.0001091544,0.001244254],"study_design_scores_gemma":[0.00001582796,0.0001848767,0.05805198,0.000007999768,0.00001793254,0.0004623707,0.00006549104,0.001421891,0.933041,0.0001769972,0.006544962,0.000008716613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989544,0.005974686,0.001667411,0.0001049177,0.00004283489,0.00001758911,0.0006178347,0.0001008685,0.001929903],"genre_scores_gemma":[0.9951957,0.001144649,0.0004953941,0.0000399811,0.00001030062,0.00001226857,0.000482821,0.00001407441,0.002604861],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312601,"threshold_uncertainty_score":0.004391134,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01500981098029784,"score_gpt":0.2429118723486061,"score_spread":0.2279020613683083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}