{"id":"W4392344031","doi":"10.1016/j.scr.2024.103375","title":"Generation of three myotonic dystrophy type 1 patient iPSC lines (CBRCULi018-A, CBRCULi019-A, CBRCULi020-A) derived from lymphoblastoid cell lines for disease modelling and therapeutic research","year":2024,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"U.S. Army Medical Research Acquisition Activity; Fonds de Recherche du Québec - Santé; U.S. Department of Defense","keywords":"Myotonic dystrophy; Biology; Lymphoblast; Disease; Cell culture; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004877411,0.000384121,0.0004189438,0.0005273927,0.0004224338,0.0005553674,0.0005396547,0.0007421913,0.003260262],"category_scores_gemma":[0.0004026587,0.0001698616,0.0004479794,0.0003482102,0.0002586162,0.0001847358,0.0004062194,0.001199388,0.001349404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003384305,"about_ca_system_score_gemma":0.0004062469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009135555,"about_ca_topic_score_gemma":0.001198511,"domain_scores_codex":[0.9997057,0.00002802991,0.00006353061,0.00006498883,0.00009829159,0.00003940772],"domain_scores_gemma":[0.9997917,0.00003471755,0.00003011002,0.00003761792,0.00005697373,0.00004881948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002760854,0.0001650902,0.001088342,0.000119669,0.00002634178,0.0006073227,0.000221884,0.0002877086,0.9879681,0.0009434815,0.0007329659,0.007563012],"study_design_scores_gemma":[0.0002685523,0.0008731801,0.008184218,0.00008429863,0.0002109488,0.004417866,0.0002296747,0.00267403,0.9492842,0.000315844,0.03340912,0.00004814441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9464402,0.001851315,0.02715112,0.0004061913,0.0002322899,0.001794962,0.0100245,0.0003574867,0.0117419],"genre_scores_gemma":[0.9263671,0.002242155,0.03436999,0.000511046,0.00003891658,0.002203914,0.02216007,0.0001995089,0.01190736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003260262,"threshold_uncertainty_score":0.01090664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2665634123788228,"score_gpt":0.3693305911676249,"score_spread":0.1027671787888021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}