{"id":"W4392344031","doi":"10.1016/j.scr.2024.103375","title":"Generation of three myotonic dystrophy type 1 patient iPSC lines (CBRCULi018-A, CBRCULi019-A, CBRCULi020-A) derived from lymphoblastoid cell lines for disease modelling and therapeutic research","year":2024,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut Universitaire en Santé Mentale de Québec","funders":"U.S. Army Medical Research Acquisition Activity; Fonds de Recherche du Québec - Santé; U.S. Department of Defense","keywords":"Myotonic dystrophy; Biology; Lymphoblast; Disease; Cell culture; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008806993,0.0004061064,0.0003980734,0.0007743086,0.0007700578,0.0004856638,0.0006505086,0.0001460221,0.00006917984],"category_scores_gemma":[0.0001581563,0.0003575493,0.0001873134,0.00125704,0.0006933608,0.0002036993,0.000452711,0.0005439174,0.00009669313],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001591709,"about_ca_system_score_gemma":0.0009936612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001071017,"about_ca_topic_score_gemma":0.0000292055,"domain_scores_codex":[0.9934943,0.001208605,0.0006609719,0.001653588,0.00192496,0.001057609],"domain_scores_gemma":[0.9951945,0.002166944,0.0001021025,0.0008595532,0.001161694,0.0005152201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004896615,0.0002810695,0.0001687817,0.0005818653,0.00002050604,0.00004129361,0.0007783392,0.01935344,0.973619,0.0002736713,0.0003429436,0.004049463],"study_design_scores_gemma":[0.0004256352,0.0005217424,0.00007068522,0.0000873627,0.00003490805,9.207262e-7,0.0002045258,0.3343281,0.6621178,0.001031661,0.0009496242,0.0002271071],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9770656,0.01650995,0.002742394,0.0003146995,0.0005344839,0.002127389,0.0004248188,0.00008340857,0.0001972151],"genre_scores_gemma":[0.9959653,0.00175666,0.0004420965,0.00007278217,0.0004918312,0.0004403931,0.00006008798,0.0001308169,0.0006400185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3149746,"threshold_uncertainty_score":0.9998876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2665634123788228,"score_gpt":0.3693305911676249,"score_spread":0.1027671787888021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}