{"id":"W4392344178","doi":"10.1016/j.ijpharm.2024.123958","title":"Design of liposomal nanocarriers with a potential for combined dexamethasone and bevacizumab delivery to the eye","year":2024,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"HORIZON EUROPE Marie Sklodowska-Curie Actions; H2020 Marie Skłodowska-Curie Actions; European Commission; Queen's University; Queen's University Belfast; U.S. Department of Energy","keywords":"Liposome; Zeta potential; Nanocarriers; Drug delivery; Biocompatibility; Pharmacology; Biomedical engineering; Eye drop; Particle size; Dosage form; Bevacizumab; Chemistry; Nanotechnology; Materials science; Medicine; Surgery; Nanoparticle; Chemotherapy; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002331092,0.0003492115,0.0002156171,0.0002191721,0.0001933079,0.0005040262,0.0002942998,0.0005193259,0.001043676],"category_scores_gemma":[0.0002712953,0.0001983903,0.0003426955,0.0001360446,0.0002219848,0.0003459583,0.0002726788,0.0004190011,0.0004650033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007328885,"about_ca_system_score_gemma":0.0004965038,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001170703,"about_ca_topic_score_gemma":0.001630199,"domain_scores_codex":[0.9998764,0.00001737044,0.00001071015,0.00003327342,0.00002899097,0.00003331714],"domain_scores_gemma":[0.9999057,0.00001643165,0.00003318462,0.000006009242,0.00001800435,0.00002069793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000310527,0.00007392529,0.0001178748,0.0001117396,0.0000166979,0.0001004346,0.00002687281,0.001314284,0.989783,0.0007880565,0.0001304954,0.007225981],"study_design_scores_gemma":[0.00009893096,0.0005393067,0.0003603555,0.000009315048,0.00003617556,0.0001159882,0.00001624962,0.004319082,0.9894438,0.00009014186,0.004951825,0.0000187981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9403996,0.005077331,0.04820112,0.0005942062,0.0001713409,0.0007340813,0.0003630938,0.0002233631,0.004235977],"genre_scores_gemma":[0.9662861,0.001536729,0.02768136,0.0001710849,0.00001841651,0.0003171377,0.000150729,0.00002918219,0.003809272],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001170703,"threshold_uncertainty_score":0.00531745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07510475843808909,"score_gpt":0.4290875433756239,"score_spread":0.3539827849375348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}