{"id":"W4392344369","doi":"10.1097/qai.0000000000003395","title":"Durable Efficacy of Switching From a 3- or 4-Drug Tenofovir Alafenamide–Based Regimen to the 2-Drug Regimen Dolutegravir/Lamivudine in the TANGO Study Through Week 196","year":2024,"lang":"en","type":"article","venue":"JAIDS Journal of Acquired Immune Deficiency Syndromes","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"ViiV Healthcare; Gilead Sciences","keywords":"Dolutegravir; Regimen; Tenofovir alafenamide; Medicine; Lamivudine; Drug; Virology; Oncology; Pharmacology; Human immunodeficiency virus (HIV); Internal medicine; Virus; Viral load; Antiretroviral therapy; Hepatitis B virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008005678,0.0002986293,0.0005112265,0.0001372421,0.0002481572,0.0005018299,0.0002492772,0.0003536459,0.001657769],"category_scores_gemma":[0.0007085483,0.0001589089,0.0006319275,0.0001871335,0.0003200605,0.0003418904,0.0002243338,0.0006951244,0.0001162679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006192006,"about_ca_system_score_gemma":0.0006048143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002773113,"about_ca_topic_score_gemma":0.006782996,"domain_scores_codex":[0.9997455,0.0000891334,0.00002059769,0.00005150245,0.00002917727,0.00006397381],"domain_scores_gemma":[0.9994276,0.00008685023,0.0001847606,0.00004993133,0.00003264689,0.0002181433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6905677,0.0142146,0.1678033,0.0005940284,0.001771573,0.0004097362,0.001107952,0.0007040159,0.02636675,0.0000895577,0.001176941,0.09519384],"study_design_scores_gemma":[0.110226,0.1879317,0.692301,0.0001260464,0.001857184,0.0003768883,0.0003432915,0.0007324092,0.003995047,0.0001151973,0.001932764,0.00006244941],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991903,0.0003321156,0.00001741119,0.000032709,0.000008612082,0.00003522982,0.0001029829,0.000003492958,0.0002771745],"genre_scores_gemma":[0.9993667,0.000126312,0.00004263605,0.00005211981,0.00001291595,0.00002836003,0.0001531861,0.000001046489,0.0002167442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002773113,"threshold_uncertainty_score":0.005545855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02704949612599699,"score_gpt":0.297265296963276,"score_spread":0.270215800837279,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}